1439364-88-1Relevant articles and documents
Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer
Wang, Cong,Wang, Bin,Hou, Siyuan,Xue, Lingjing,Kang, Zisheng,Du, Junjie,Li, Yanyi,Liu, Xuwentai,Wang, Qianqian,Zhang, Can
, p. 787 - 803 (2019)
Vitamin D receptor (VDR) is recognized as a potential target for the treatment of breast cancer which is the most common malignancy among women in the world. In this study, a series of nonsecosteroidal VDR agonists with a novel diarylmethane skeleton was
Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p-Toluenesulfonate
Komeyama, Kimihiro,Yamahata, Yuta,Osaka, Itaru
supporting information, p. 4375 - 4378 (2018/07/29)
Herein, a novel approach for the trideuteriomethylation of aryl halides using nickel and nucleophilic cobalt catalysts and the readily available trideuteriomethyl p-toluenesulfonate (CD3OTs) is described. This method provides access to a wide r
Further Developments of the Phenyl-Pyrrolyl Pentane Series of Nonsteroidal Vitamin D Receptor Modulators as Anticancer Agents
Hao, Meixi,Hou, Siyuan,Xue, Lingjing,Yuan, Haoliang,Zhu, Lulu,Wang, Cong,Wang, Bin,Tang, Chunming,Zhang, Can
, p. 3059 - 3075 (2018/04/23)
The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential molecular target for anticancer-drug discovery. In this study, a series of nonsteroidal vitamin D mimics with phenyl-pyrrolyl pentane skeletons wit
Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton
Shen, Wei,Xue, Jingwei,Zhao, Zekai,Zhang, Can
, p. 768 - 778 (2013/10/22)
In order to find the vitamin D receptor (VDR) ligand whose VDR agonistic activity is separated from the calcemic activity sufficiently, novel nonsecosteroidal analogs with phenyl-pyrrolyl pentane skeleton were synthesized and evaluated for the VDR binding
