1439376-72-3Relevant academic research and scientific papers
Divergent total synthesis of the antimitotic agent leiodermatolide
Willwacher, Jens,Kausch-Busies, Nina,Fürstner, Alois
, p. 12041 - 12046 (2012)
Subtle but distinctive: The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring-closing alkyne metathesis as the key step has now solved the p
Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide
Mailhol, Damien,Willwacher, Jens,Kausch-Busies, Nina,Rubitski, Elizabeth E.,Sobol, Zhanna,Schuler, Maik,Lam, My-Hanh,Musto, Sylvia,Loganzo, Frank,Maderna, Andreas,Fürstner, Alois
, p. 15719 - 15729 (2014/12/11)
It was by way of total synthesis that the issues concerning the stereostructure of leiodermatolide (1) have recently been solved; with the target now being unambiguously defined, the mission of synthesis changes as to secure a meaningful supply of this ex
