1439388-75-6Relevant academic research and scientific papers
Formation of 8-S-L-cysteinylguanosine from 8-bromoguanosine and cysteine
Suzuki, Toshinori,Kosaka, Aya,Inukai, Michiyo
, p. 3864 - 3867 (2013)
When 8-bromoguanosine was incubated with cysteine at pH 7.4 and 37 C, a previously unidentified product was formed as a major product in addition to guanosine. The product was identified as a cysteine substitution derivative of guanosine at the 8 position, 8-S-l-cysteinylguanosine. The reaction was accelerated under mildly basic conditions. The cysteine adduct of guanosine was fairly stable and decomposed with a half-life of 193 h at pH 7.4 and 37 C. Similar results were observed for incubation of 8-bromo-2′-deoxyguanosine with cysteine. The results suggest that 8-bromoguanine in nucleosides, nucleotides, RNA, and DNA can react with thiols resulting in stable adducts.
