143943-71-9

Upstream product

• 201230-82-2 carbon monoxide 
• 164790-63-0 1-Bromo-10-chloro-3-phenyl-6,7-dihydro-pyrido[2,1-a]isoquinolin-4-one 
• 104728-19-0 9-chloro-5,6-dihydro-2-phenylthiazolo<2,3-a>isoquinolin-4-ium 3-oxide 
• 26406-59-7 7-chloro-3,4-dihydroisoquinoline-1(2H)-thione 
• 104604-73-1 methyl 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylate 

Downstream Products

• 165611-16-5 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride 
• 104603-96-5 10-chloro-6,7-dihydro-1-<(morpholin-4-yl)carbonyl>-3-phenyl-4H-benzoquinolizin-4-one 
• 104603-97-6 10-chloro-1-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-6,7-dihydro-3-phenyl-4H-benzoquinolizin-4-one 
• 104628-92-4 10-chloro-N-<2-(dimethylamino)ethyl>-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizin-1-carboxamide hydrochloride 
• 143943-73-1 (S)-10-chloro-1-(3-ethoxypyrrolidin-1-yl)-3-phenyl-6,7-dihydro-4H-benzoquinolizin-4-one 
• 104604-44-6 6,7-dihydro-1-(hydroxymethyl)-3-phenyl-10-chloro-4H-benzo[a]quinolizin-4-one 
• 104587-32-8 (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-2-pyrrolidinemethanol 
• 104587-30-6 1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-3-pyrrolidinol 
• 104604-08-2 10-chloro-N-(4,5-dihydro-2-thiazolinyl)-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-carboxamide 
• 143943-72-0 (S)-1-[ (10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-3-hydroxypyrrolidine 

Relevant academic research and scientific papers

Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative

The invention is concerned with a process for the preparation of a benzo[a]quinolizinone derivative of the formula STR1 by reacting a compound of the formula STR2 wherein X is halogen and Ph is phenyl, with carbon monoxide in the presence of a carbonylati

An Expedient Route to the Tricyclic Pyridone Derivative Ro 41-3696, a Novel Non-Benzodiazepine Sleep Inducer

A short, technical synthesis of (S)-10-chloro-1-(3-ethoxypyrrolidin-1-yl)-3-phenyl-6,7-dihydro-4H-benzoquinolizin-4-one (1) from 2-(4-chlorophenyl)ethylamine (2) is described.

78. Tricyclic pyridine derivatives with high affinity to the central benzodiazepine receptor

Novel tricyclic heterocycles were prepared and evaluated for their affinity to the central benzodiazepine receptor. The most potent compounds with IC50's in the nanomolar range were found among thienoquinolizines and benzo[a]quinolizines (cf. Tables 2-5). The central ring of the tricyclic ring system may be partially unsaturated (cf. Tables 2 and 4) or fully unsaturated (cf. Tables 3 and 5) without loss of the high affinity to the receptor. The position of the ester group in the pyridinone ring is crucial for good binding (cf. Tables 1 and 2). It may be replaced by a broad variety of functional groups, e.g., amides, alkyl carbamates, alkyl groups, and hydroxyalkyl groups (cf. Tables 2-5). In the benzo[a]quinolizines, shifting the halogen atom from C(10) to C(9) leads to complete loss of affinity to the benzodiazepine receptor (cf. Table 4).

Tricyclic pyridine derivatives and pharmaceutical compositions

Compounds of the formula STR1 or a pharmaceutically acceptable acid addition salt of a compound of formula I which has one or more basic substituents, are described. The compounds of formula I possess pronounced muscle relaxant, sedative-hypnotic, anticonvulsive and anxiolytic properties and have low toxicity.