26406-59-7

Basic information

• Product Name: 7-chloro-3,4-dihydro-2H-isoquinoline-1-thione
• Synonyms: 7-chloro-3,4-dihydro-2H-isoquinoline-1-thione
• CAS NO: 26406-59-7
• Molecular Formula: C9H8ClNS
• Molecular Weight: 197.68
• Mol File: 26406-59-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 189.5 - 190.5 °C
• CAS DataBase Reference: 7-chloro-3,4-dihydro-2H-isoquinoline-1-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-3,4-dihydro-2H-isoquinoline-1-thione(26406-59-7)
• EPA Substance Registry System: 7-chloro-3,4-dihydro-2H-isoquinoline-1-thione(26406-59-7)

Safety Data

• Hazardous Substances Data: 26406-59-7(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 156-41-2 4-chlorophenylethylamine 
• 701281-96-1 1-(4-chlorophenethyl)-3-(4-nitrophenyl)thiourea 
• 17608-10-5 2-(4-chlorophenyl)ethyl isothiocyanate 

Downstream Products

• 104628-92-4 10-chloro-N-<2-(dimethylamino)ethyl>-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizin-1-carboxamide hydrochloride 
• 104603-97-6 10-chloro-1-<(cis-2,6-dimethylmorpholin-4-yl)carbonyl>-6,7-dihydro-3-phenyl-4H-benzoquinolizin-4-one 
• 104603-96-5 10-chloro-6,7-dihydro-1-<(morpholin-4-yl)carbonyl>-3-phenyl-4H-benzoquinolizin-4-one 
• 104628-85-5 methyl 10-chloro-3-(4-chlorophenyl)-6,7-dihydro-4-oxo-4H-benzoquinolizine-1-carboxylate 
• 143943-71-9 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylic acid 
• 165611-16-5 10-Chloro-4-oxo-3-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride 
• 104604-73-1 methyl 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzoquinolizine-1-carboxylate 
• 200216-62-2 10-Chloro-4-oxo-3-phenyl-3,4,6,7-tetrahydro-2H-pyrido[2,1-a]isoquinoline-1-carboxylic acid ethyl ester 
• 104728-19-0 9-chloro-5,6-dihydro-2-phenylthiazolo<2,3-a>isoquinolin-4-ium 3-oxide 
• 104728-20-3 9-chloro-2-(4-chlorophenyl)-5,6-dihydrothiazolo<2,3-a>isoquinolin-4-ium 3-oxide 

Relevant articles and documents

TfOH-Promoted Transition-Metal-Free Cascade Trifluoroethylation/Cyclization of Organic Isothiocyanates by Phenyl(2,2,2-trifluoroethyl)iodonium Triflate

An efficient and transition-metal-free method for the synthesis of the structurally diversified trifluoroethylthiol phenanthridines and 3,4-dihydroisoquinolines is described. Various 2-isothiocyanobiaryls and aryl alkyl isothiocyanates reacted with phenyl(2,2,2-trifluoroethyl)iodonium triflate in CH2Cl2 in the presence of trifluoromethanesulfonic acid at 40 °C to form the corresponding trifluoroethylation/cyclization products in good to quantitative yields. This work represents the first construction of trifluoroethylthiol phenanthridine and isoquinoline derivatives from isothiocyanates in the absence of transition-metal catalysts by a one-pot procedure.

Aza-annulation as a versatile approach to the synthesis of non-benzodiazepene compounds for the treatment of sleep disorders

The aza-annulation of enamino ester substrates has been demonstrated as an efficient alternative to the syntheses of non-benzodiazepine sleep inducers. Enamino ester substrates derived from aryl, thiophene, and indole functionally were prepared from the c