143946-48-9 Usage
General Description
4-Chloro-5-methylquinoline is a chemical compound with the molecular formula C10H8ClN. It is a yellowish powder that is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 4-CHLORO-5-METHYLQUINOLINE is a quinoline derivative, which is a type of heterocyclic aromatic compound. Quinoline compounds have been studied for their potential anti-inflammatory, anti-cancer, and anti-malarial properties. 4-Chloro-5-methylquinoline is primarily used as a building block in the synthesis of other complex organic compounds, and its diverse applications make it an important compound in various chemical industries. It is important to handle this chemical with care, as it can be harmful if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 143946-48-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,9,4 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 143946-48:
(8*1)+(7*4)+(6*3)+(5*9)+(4*4)+(3*6)+(2*4)+(1*8)=149
149 % 10 = 9
So 143946-48-9 is a valid CAS Registry Number.
143946-48-9Relevant articles and documents
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities
Madrid, Peter B.,Sherrill, John,Liou, Ally P.,Weisman, Jennifer L.,DeRisi, Joseph L.,Guy, R. Kiplin
, p. 1015 - 1018 (2007/10/03)
A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.
