25063-50-7

Upstream product

• 15568-86-2 5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 108-44-1 1-amino-3-methylbenzene 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 82121-08-2 4-hydroxy-7-methylquinoline 
• 848128-81-4 5-methyl-quinolin-4-ol 
• 63136-61-8 4-chloro-7-methyl-quinoline 
• 143946-48-9 4-chloro-5-methylquinoline 

Relevant academic research and scientific papers

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.

Exotic amino acids. 8. Synthesis of monomethyl esters of N-aryl-aminomethylenemalonic acids

N-Arylaminomethyleneisopropylidenemalonates, obtained from ethoxymethyleneisopropylidenemalonate and aromatic amines, underwent methanolysis to form monomethyl esters of N-arylaminomethylenemalonic acids. The conditions of their formation and their yields depend on the nature and positions of the substituents in the aromatic ring of the initial amine.