1439559-63-3

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 3964-56-5 4-bromo-2-chlorophenol 
• 870777-25-6 (3-chloro-4-((4-methoxybenzyl)oxy)phenyl)boronic acid 
• 1026089-27-9 4-bromo-2-chloro-1-((4-methoxybenzyl)oxy)benzene 

Downstream Products

• 1439559-77-9 4-((3-chloro-4-hydroxyphenoxy)methyl)-2,2,6,6-tetramethylpiperidin-N-oxide 
• 1439559-83-7 2-(2-chloro-4-((1-oxy-2,2,6,6-tetramethylpiperidin-4-yl)methoxy)phenoxy)-6-(pyrimidin-4-yl)benzonitrile 
• 1377997-44-8 2-(2-chloro-4-((2,2,6,6-tetramethylpiperidin-4-yl)methoxy)phenoxy)-6-(pyrimidin-4-yl)benzonitrile 
• 1439559-70-2 4-((3-chloro-4-((4-methoxybenzyl)oxy)phenoxy)methyl)-2,2,6,6-tetramethylpiperidin-N-oxide 

Relevant academic research and scientific papers

Discovery and optimization of tetramethylpiperidinyl benzamides as inhibitors of EZH2

The identification and development of a novel series of small molecule Enhancer of Zeste Homologue 2 (EZH2) inhibitors is described. A concise and modular synthesis enabled the rapid development of structure-activity relationships, which led to the identification of 44 as a potent, SAM-competitive inhibitor of EZH2 that dose-dependently decreased global H3K27me3 in KARPAS-422 lymphoma cells.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.