1439667-66-9Relevant academic research and scientific papers
Stereoselective synthesis of trifluoromethyl analogues of polyhydroxypyrrolidines
Khangarot, Rama K.,Kaliappan, Krishna P.
, p. 2692 - 2698 (2013)
Incorporation of fluorine atoms into organic molecules significantly enhances many of their properties, such as solubility, metabolic stability, and bioavailability. Among organofluorine molecules, trifluoromethylated compounds play a unique and important role in agricultural and medicinal chemistry. An efficient strategy for the synthesis of a variety of trifluoromethylated polyhydroxypyrrolidines is described. This strategy involves a diastereoselective nucleophilic addition reaciton of trimethyl(trifluoromethyl) silane to sugar-derived cyclic nitrones followed by reductive N-O bond cleavage and removal of benzyl groups. An efficient strategy for the synthesis of a variety of trifluoromethylated polyhydroxypyrrolidines is described. This strategy involves a diastereoselective nucleophilic addition reaction of trimethyl(trifluoromethyl)silane to sugar-derived cyclic nitrones followed by reductive N-O bond cleavage and removal of benzyl groups. Copyright
