14397-16-1

Basic information

• Product Name: N-2-isonicotinoyl-4-phenyl-thiazol-2-amine
• Synonyms: N-2-isonicotinoyl-4-phenyl-thiazol-2-amine
• CAS NO: 14397-16-1
• Molecular Weight: 281.338
• Mol File: 14397-16-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-2-isonicotinoyl-4-phenyl-thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-isonicotinoyl-4-phenyl-thiazol-2-amine(14397-16-1)
• EPA Substance Registry System: N-2-isonicotinoyl-4-phenyl-thiazol-2-amine(14397-16-1)

Safety Data

• Hazardous Substances Data: 14397-16-1(Hazardous Substances Data)

Upstream product

• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 2010-06-2 2-Amino-4-phenylthiazole 
• 872-85-5 pyridine-4-carbaldehyde 
• 98-86-2 acetophenone 
• 55-22-1 pyridine-4-carboxylic acid 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

Synthesis of carboxamide and sulfonyl carboxamide linked heterocycles under green conditions

Direct coupling of heteroaldehydes with heteroaryl amines / sulfonylamines is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines.

2-AMINOTHIAZOLE DERIVATIVES AND METHODS OF PREPARING AND USING THE SAME

2-aminothiazole derivatives represented by formula (I), where R1 and R2 represent cycloalkyls, respectively; or R1 represents a substituted aromatic group, and R2 represents H, a C1-C11 alkyl, —CH2Ph (benzyl), or a methyl ether including a C1-C11 alkyl. R3 is a substituent including an amino group. X represents a carbonyl or a methylene and n is an integer from 0 to 5.

Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-Ribose) polymerase-1 inhibitors

A series of novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors were designed within 2-aminothiazole analogues (4-10) based on a constructed three-dimensional pharmacophore model. After synthesis, the inhibitory effect on PARP-1 activity and the cytoprotective action of these compounds were tested and evaluated. Among them, compounds 4-6 and 10 appeared to be potent PARP-1 inhibitors with IC50 values less than 1 μM, which had been perfectly predicted by pharmacophore model. These compounds proved to be highly potent against cell injury induced by H2O2 and oxygen-glucose deprivation (OGD) in PC12 cells. These novel 2-aminothiazole analogues are potentially applicable as neuroprotective agents for the treatment of neurological diseases.