1439725-01-5Relevant academic research and scientific papers
Stereoselective synthesis of the C31-C41 spirolactam fragment of sanglifehrin a
Yadav,Raghavendra Rao,Kavita, Aala,Mohapatra, Debendra K.
, p. 2849 - 2858 (2013)
A stereoselective synthesis of the spirolactam fragment (C31-C41) of a highly-potent immunosuppressant sanglifehrin A is described. The key steps involved in this synthesis are a desymmetrization protocol, Sharpless asymmetric epoxidation, Crimmins syn aldol reaction, Barton-McCombie deoxygenation, and acid-mediated spirolactamization. Copyright
