Stereoselective synthesis of the C31-C41 spirolactam fragment of sanglifehrin a

DOI: 10.1002/ejoc.201201684

Source and publish data:

European Journal of Organic Chemistry p. 2849 - 2858 (2013)

Update date:2022-07-31

Topics:

Authors:

Yadav Yadav

Raghavendra Rao

Kavita, Aala

Mohapatra, Debendra K.

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Article abstract of DOI:10.1002/ejoc.201201684

A stereoselective synthesis of the spirolactam fragment (C31-C41) of a highly-potent immunosuppressant sanglifehrin A is described. The key steps involved in this synthesis are a desymmetrization protocol, Sharpless asymmetric epoxidation, Crimmins syn aldol reaction, Barton-McCombie deoxygenation, and acid-mediated spirolactamization. Copyright

Full text of DOI:10.1002/ejoc.201201684

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