14398-99-3Relevant articles and documents
Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones
Hutchings, Kim M.,Tran, Tuan P.,Ellsworth, Edmund L.,Watson, Brian M.,Sanchez, Joseph P.,Hollis Showalter,Stier, Michael A.,Shapiro, Martin,Themis Joannides,Huband, Michael,Nguyen, Dai Q.,Maiti, Samarendra,Li, Tingsheng,Tailor, Jyoti,Thomas, George,Ha, Chan,Singh, Rajeshwar
scheme or table, p. 5087 - 5090 (2009/05/07)
A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.
N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents
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, (2008/06/13)
Novel compounds of the formula below wherein W is azetidine, pyrrolidine or piperidine, Q is a straight chain hydrocarbon radical of 1-4 carbons and may contain a double bond, and STR1 Ar is phenyl, pyridinyl or pyrimidinyl, a process for their preparation, and novel intermediates are disclosed. The novel compounds and the pharmaceutical compositions of this invention are useful in the treatment of hypertension, arrhythmias and angina.