1439933-34-2

Upstream product

• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 15761-50-9 2-amino-4-methylpentane 
• 1439933-32-0 1-((2'-(tert-butoxycarbonyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-5-carboxylic acid 
• 26663-77-4 methyl 1H-benzo[d]imidazole-5-carboxylate 

Downstream Products

• 1439933-06-8 4'-((5-((4-methylpentan-2-yl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid 

Relevant academic research and scientific papers

N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG

The invention provides molecular entities that bind with high affinity to PPARG (PPAR?), inhibit cdk5-mediated phosphorylation of PPARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes or obesity. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.