15761-50-9

Basic information

• Product Name: (R)-4-amino-2-methylpentane
• Synonyms: (R)-4-amino-2-methylpentane
• CAS NO: 15761-50-9
• Molecular Weight: 101.192
• Mol File: 15761-50-9.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: (R)-4-amino-2-methylpentane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-amino-2-methylpentane(15761-50-9)
• EPA Substance Registry System: (R)-4-amino-2-methylpentane(15761-50-9)

Safety Data

• Hazardous Substances Data: 15761-50-9(Hazardous Substances Data)

Upstream product

• 53867-52-0 bis-(1,3-dimethyl-butylidene)-hydrazine 
• 105-44-2 4-methyl-pentan-2-one oxime 
• 108-10-1 4-methyl-2-pentanone 
• 64-17-5 ethanol 
• 2158-24-9 4-methyl-pent-3-en-2-one oxime 
• 1258934-39-2 N-(4-methylpentan-2-yl)pyrimidine-2-sulfonamide 
• 68-11-1 mercaptoacetic acid 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 7533-40-6 2-amino-4-methyl-1-pentanol 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 2550-26-7 4-Phenyl-2-butanone 
• 75240-54-9 N-(4-methylpentan-2-yl)formamide 
• 26842-43-3 2-amino-2,4-dimethylpentanonitrile 
• 67-56-1 methanol 

Downstream Products

• 42966-64-3 N-ethyl-1,3-dimethylbutylamine 
• 42966-66-5 cyclohexyl-(1,3-dimethyl-butyl)-amine 
• 40092-95-3 C₁₅H₂₂ClN₃O 
• 20640-02-2 2-<4-Methyl-2-pentylamino>-aethanthiol 
• 95945-86-1 (1,3-dimethyl-butyl)-[1-methyl-3-(2,6,6-trimethyl-cyclohex-1-enyl)-propyl]-amine 
• 40487-41-0 (1,3-Dimethyl-butyl)-(3,4-dimethyl-2,6-dinitro-phenyl)-amine 
• 40318-81-8 4-chloro-2,6-dinitro-N-(1,3-dimethylbutyl)-m-toluidine 
• 67330-79-4 1-(2,6-Diethyl-4-methyl-phenyl)-3-(1,3-dimethyl-butyl)-thiourea 
• 38008-69-4 (1,3-Dimethyl-butyl)-carbamic acid 3-methylsulfanylcarbonylamino-phenyl ester 
• 32781-26-3 (1,3-dimethyl-butyl)-(1,3-dimethyl-butyliden)-amine 
• 30121-94-9 4-{[(E)-1,3-Dimethyl-butylimino]-methyl}-phenol 
• 1187092-65-4 N-(4-methylpentan-2-yl)-3-phenylpropanamide 
• 34017-00-0 N-(4-methylpentan-2-yl)benzamide 
• 1439933-06-8 4'-((5-((4-methylpentan-2-yl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid 

Relevant articles and documents

Biochemical and Structural Characterization of an (R)-Selective Transaminase in the Asymmetric Synthesis of Chiral Hydroxy Amines

An (R)-selective transaminase RbTA with excellent stereoselectivity (>99% ee) in the asymmetric amination of hydroxy ketones was identified. Biochemical characterization showed that RbTA exhibited the highest activity toward 4-hydroxy-2-butanone among reported enzymes, and that it has broad substrate specificity, including for aliphatic, aromatic, and alicyclic ketones. Crystallization of RbTA were performed, as were molecular docking and mutagenesis studies. Residue Tyr125 plays a key role in substrate recognition by forming a hydrogen bond with hydroxy ketone. The applicability of the enzyme was determined in preparative-scale synthesis of (R)-3-amino-1-butanol, demonstrating the potential of RbTA as a green biocatalyst for production of value-added chiral hydroxy amines. This study provides an efficient tool for enzymatic synthesis of chiral hydroxy amines, as well as structural insight into substrate recognition by transaminases in the asymmetric amination of hydroxy ketones. (Figure presented.).

An Ammonium-Formate-Driven Trienzymatic Cascade for ω-Transaminase-Catalyzed (R)-Selective Amination

(R)-Amination mediated by (R)-specific ω-transaminases generally requires costly d-alanine in excess to obtain the desired chiral amines in high yield. Herein, a one-pot, trienzymatic cascade comprising an (R)-specific ω-transaminase, an amine dehydrogenase, and a formate dehydrogenase was developed for the economical and eco-friendly synthesis of (R)-chiral amines. Using inexpensive ammonium formate as the sole sacrificial agent, the established cascade system enabled efficient ω-transaminase-mediated (R)-amination of various ketones, with high conversions and excellent ee (>99%); water and CO2 were the only waste products.

Rapid synthesis method of biomass-based amide

The invention discloses a rapid synthesis method of biomass-based amide, which comprises the steps: formamide is used as an amine source, formic acid is used as a hydrogen source, biomass aldehyde andketone is used as a raw material, the direct addition of formamide and aldehyde and ketone components and the reduction of formic acid is promoted to prepare the corresponding formamide derivative byrapidly heating under microwave-assisted heating and in the absence of a solvent and a catalyst; the formamide derivative is selectively converted to the corresponding primary amide by alcoholysis under the action of a base. The microwave assisted heating reaction system of the invention has higher catalytic efficiency than the corresponding oil bath system, greatly shortens the reaction time, remarkably improves the selectivity. The conversion rate of the biomass aldehyde or ketone compound is at least 99%, and the yield of the formamide derivative can reach 85 to 99%; the formamide can be synthesized by alcoholysis to obtain a primary amide with a yield of 92 to 99%.