1440084-83-2Relevant academic research and scientific papers
Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics
Jin, Meizhong,Petronella, Brenda A.,Cooke, Andy,Kadalbajoo, Mridula,Siu, Kam W.,Kleinberg, Andrew,May, Earl W.,Gokhale, Prafulla C.,Schulz, Ryan,Kahler, Jennifer,Bittner, Mark A.,Foreman, Kenneth,Pachter, Jonathan A.,Wild, Robert,Epstein, David,Mulvihill, Mark J.
, p. 627 - 631 (2013/07/26)
This letter describes a series of small molecule inhibitors of IGF-1R with unique time-dependent binding kinetics and slow off-rates. Structure-activity and structure-kinetic relationships were elucidated and guided further optimizations within the series
