110802-16-9Relevant articles and documents
QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS
-
Page/Page column 43, (2014/10/03)
The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.
Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics
Jin, Meizhong,Petronella, Brenda A.,Cooke, Andy,Kadalbajoo, Mridula,Siu, Kam W.,Kleinberg, Andrew,May, Earl W.,Gokhale, Prafulla C.,Schulz, Ryan,Kahler, Jennifer,Bittner, Mark A.,Foreman, Kenneth,Pachter, Jonathan A.,Wild, Robert,Epstein, David,Mulvihill, Mark J.
supporting information, p. 627 - 631 (2013/07/26)
This letter describes a series of small molecule inhibitors of IGF-1R with unique time-dependent binding kinetics and slow off-rates. Structure-activity and structure-kinetic relationships were elucidated and guided further optimizations within the series
DEUTERATED TYROSINE KINASE INHIBITORS
-
Page/Page column 21-22, (2011/06/16)
Compounds of Formula I, as shown below and defined herein: enriched in deuterium, and pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in par
Amides derived from quinoline, and anxiolytic compositions containing them
-
, (2008/06/13)
Compounds of formula: STR1 in which V and W are H, halogen, alkyl (1-4C) or alkoxy (1-4C), amino, or acylamino,Z is phenyl, optionally substituted, thienyl, or pyridyl,R 1 is alkyl (1-6C), alkoxyalkyl, cycloalkyl (3-6C), phenyl, phenylalkyl, or cycloalkyl