144015-84-9

Upstream product

• 17690-16-3 benzyl bromomethyl ether 
• 127104-06-7 (3S)-<6,6-2H2>-3,6-dihydro-2,5-dimethoxy-3-(1-methylethyl)pyrazine 
• 3587-60-8 Benzyloxymethyl chloride 
• 78342-42-4 (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine 

Downstream Products

• 4070-48-8 L-Valine methyl ester 
• 143687-03-0 (2R)-<2-2H>-O-benzylserine methyl ester 

Relevant academic research and scientific papers

Stereospecific Synthesis of α-Deuteriated α-Amino Acids: Regiospecific Deuteriation of Chiral 3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazines

Base-catalysed deuteriation of (3R)- or (3S)-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazines in refluxing CH3O2H-2H2O gives the -isotopomer in excellent yields without disturbing the stereogenic centre at C-3.These compounds provide convenient and efficient access to a range of (R)- and (S)-α-deuteriated α-amino acids, including serine, aspartic acid, allylglycine and phenylalanine, via alkylation of the butyllithium generated C-6 anion.

Regiospecific Deuteriation of Chiral 3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazines in the Stereospecific Synthesis of α-Deuteriated α-Amino Acids

Base-catalysed deuteriation of (3R)- or (3S)-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine in refluxing CH3O(2)H-(2)H2O gives the isotopomer in excellent yield without disturbing the stereogenic centre at C-3, and thus providing convenient and e