1440198-44-6Relevant articles and documents
Highly diastereo- and enantioselective organocatalytic one-pot sequential 1,4-addition/dearomative-fluorination transformation
Li, Feng,Sun, Long,Teng, Yuou,Yu, Peng,Zhao, John Cong-Gui,Ma, Jun-An
supporting information, p. 14255 - 14260 (2013/01/15)
Fluorination: A wide range of nitroolefins and pyrazol-5-ones undergo a sequential 1,4-addition/dearomative-fluorination transformation when treated with a catalytic amount of a tertiary-amine-thiourea compound and the terminal electrophile, N-fluorobenzenesulfonimide, to give fluorinated products in 72-95 % yield with up to 99:1 d.r. and 98 % ee. Notably, these products contain adjacent tertiary and α-fluoro quaternary stereocenters (see scheme). Copyright