1440200-00-9

Basic information

• Product Name: (R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol
• Synonyms: (R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol
• CAS NO: 1440200-00-9
• Molecular Weight: 323.351
• Mol File: 1440200-00-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol(1440200-00-9)
• EPA Substance Registry System: (R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol(1440200-00-9)

Safety Data

• Hazardous Substances Data: 1440200-00-9(Hazardous Substances Data)

Upstream product

• 5153-67-3 nitrostyrene 
• 89-25-8 edaravone 
• 102-96-5 (2-nitroethenyl)benzene 

Downstream Products

• 1440200-09-8 5-methoxy-3-methyl-4-(2-nitro-1-phenylethyl)-1-phenyl-1H-pyrazole 
• 1440200-12-3 3-methyl-4-(2-nitro-1-phenylethyl)-1-phenyl-1H-pyrazol-5-yl acetate 
• 1440198-84-4 4-fluoro-3-methyl-4-(2-nitro-1-phenylethyl)-1-phenyl-1H-pyrazol-5(4H)-one 
• 1451195-32-6 C₂₁H₁₉N₃O₃ 

Relevant articles and documents

Enantioselective Conjugate Addition of Pyrazolones to Nitroalkenes Catalyzed by Binaphthyl-modified Squaramide Organocatalyst

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Highly enantioselective Michael addition of pyrazolin-5-ones to nitroolefins catalyzed by cinchona alkaloid derived 4-methylbenzoylthioureas

Cinchona alkaloid-derived 4-methyl/nitro benzoylthioureas were synthesized, which smoothly catalyzed the asymmetric Michael addition of pyrazolin-5-ones to nitroolefins. The results showed that electronic effects of substituents in the benzene ring of benzoylthioureas have subtle influences on their catalytic abilities and electron donating methyl group is favored than electron withdrawing nitro group. Preliminary Hartree-Fock calculations revealed that in the catalytic cycle, hydrogen bond energies of the complex formed with 4-methylbenzoylthioureas are about 0.19 to 1.56?kcal/mol higher than with the corresponding 4-nitrobenzoylthioureas. 4-Methylbenzoylthioureas were identified as the most effective catalysts that promoted asymmetric Michael addition of pyrazolin-5-ones to nitroolefins to give the S- or R-products with high enantioselectivities.

Asymmetric cooperative catalysis in the conjugate addition of pyrazolones to nitroolefins and subsequent dearomative chlorination

Over the past decade many bifunctional amine-thioureas have been developed as active metal-free organocatalysts. Cooperative catalysis of these amino-thioureas allows high reaction rates and excellent transfer of stereochemical information. Despite these impressive advances, the design of new high-performance catalysts for applications in asymmetric catalytic reactions is of ongoing interest in organic chemistry. Herein we describe a cooperative catalyst system consisting of a chiral aminethiourea and an achiral organic acid that promotes the conjugate addition of 4-nonsubstituted pyrazolones to nitroolefins and subsequent dearomative chlorination. The corresponding adducts and the subsequent products were obtained in high to excellent yields (up to 99%) and high stereoselectivities (up to 99/1 dr, 98% ee) under mild reaction conditions. These transformations provide an easy access to enantio-enriched pyrazole derivatives, which could possess potential pharmaceutical activity.