144024-33-9 Usage
Indole ring structure
A bicyclic aromatic ring system consisting of a 6-membered benzene ring fused to a 5-membered nitrogen-containing ring.
Chloroethyl group
A vinyl chloride substituent attached to an ethyl group, which introduces a chlorine atom to the molecule.
Hydroxymethyl ether group
A group consisting of an oxygen atom bonded to an ethyl group and a hydroxyl group, which can participate in hydrogen bonding and increase the compound's solubility in polar solvents.
Sulfonyl group
An organic functional group consisting of a sulfur atom double-bonded to two oxygen atoms, which can enhance the compound's reactivity and polarity.
4-Methylphenyl substituent
A phenyl ring with a methyl group attached to the 4-position, which can influence the compound's steric properties and electronic effects.
Potential chemical reactivity
The presence of multiple functional groups can lead to various chemical reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and oxidation.
Biological activity
The compound's unique structure and functional groups may contribute to its potential as a pharmaceutical agent or biological probe.
Diverse applications
Due to its unique structure and functional properties, the compound may be used in a range of chemical, pharmaceutical, and biological applications, such as drug development, chemical synthesis, and molecular research.
Check Digit Verification of cas no
The CAS Registry Mumber 144024-33-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,2 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 144024-33:
(8*1)+(7*4)+(6*4)+(5*0)+(4*2)+(3*4)+(2*3)+(1*3)=89
89 % 10 = 9
So 144024-33-9 is a valid CAS Registry Number.
144024-33-9Relevant academic research and scientific papers
Preparation of alkyl-substituted indoles in the benzene portion. Part 7. Synthesis of (±)- and (S)-(-)-pindolol
Fuji,Muratake,Akiyama,Natsume
, p. 2353 - 2357 (2007/10/02)
A new, short-step synthesis of a β-adrenergic blocking agent, pindolol, 1-(4-indolyloxy)-3-(2-propylamino)-2-propanol, is described. The acid-catalyzed indole cyclization reaction of 4-[1-(4-methylphenyl)sulfonyl-3-pyrrolyl]-4-oxobutanal (14) in the presence of (±)-3-chloro-1,2-propanediol (12) and (R)-1-O-[(4-methylphenyl)sulfonyl]glycerol (24) afforded (±)-1-chloro-3-[1-(4-methylphenyl)sulfonyl-4-indolyloxy]-2-propanol (15) and (R)-(-)-3-[1-(4-methylphenyl)sulfonyl-4-indolyloxy]-1-[(4-methylphenyl sulfonyloxy]-2-propanol (25). Reaction of these with isopropylamine and removal of the protecting group at the indole nitrogen gave (±)- and (S)-(-)-pindolol (3 and 4), thus constituting an efficient three-step synthesis of 3 and 4 from the readily available aldehyde (14).
Preparation of alkyl-substituted indoles in the benzene portion. Part 8. Improved practical synthesis of 4,4-dialkoxy-1-(1-arylsulfonyl-3-pyrrolyl)-1-butanone and 4-(1-arylsulfonyl-3-pyrrolyl)-4-oxobutanal, and a novel synthetic procedure for 4-alkoxyindole derivatives
Utsunomiya,Muratake,Natsume
, p. 2358 - 2361 (2007/10/02)
Important precursors (1 and 2) for the synthesis of 4-substituted indole derivatives were readily obtained by acid treatment of a tosylamide (13), which was prepared in a single operation by treatment of 10 with N-tosyl-N',N'-dimethylformamidine (TsN=CHNMe2). Compound (10) was effectively synthesized from nitromethane and acrolein by way of a nitro compound (15). A novel indole formation reaction from the tosyl-amide (13) to gain short access to 4-alkoxyindoles, such as 16, 17, 19, and 21 is presented.
