144024-32-8

Basic information

• Product Name: 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal
• Synonyms: 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal
• CAS NO: 144024-32-8
• Molecular Weight: 305.354
• Mol File: 144024-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal(CAS DataBase Reference)
• NIST Chemistry Reference: 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal(144024-32-8)
• EPA Substance Registry System: 4-<1-(4-methylphenyl)sulfonyl-3-pyrrolyl>-4-oxobutanal(144024-32-8)

Safety Data

• Hazardous Substances Data: 144024-32-8(Hazardous Substances Data)

Upstream product

• 147189-46-6 3-formyl-1,1,7,7-tetramethoxy-4-heptanone 
• 147189-49-9 4-nitro-1,1,7,7-tetramethoxyheptane 
• 147189-47-7 3-aminomethylene-1,1,7,7-tetramethoxy-4-heptanone 
• 147189-45-5 1,1,7,7-tetramethoxy-4-heptanone 
• 147189-43-3 4-nitroheptanedial 
• 147189-44-4 1,1,7,7-tetramethoxy-4-heptanol 
• 147189-48-8 3-<4-(methylphenyl)sulfonylaminomethylene>-1,1,7,7-tetramethoxy-4-heptanone 

Downstream Products

• 144024-33-9 3-chloro-2-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-1-propanol 
• 76989-09-8 1-chloro-3-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-2-propanol 
• 144024-36-2 (S)-(-)-1-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-3-(2-propylamino)-2-propanol 
• 13523-86-9 1-(1H-indol-4-yloxy)-3-(isopropylamino)-2-propanol 
• 144024-35-1 (R)-(+)-2-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-3-<(4-methylphenyl)sulfonyloxy>-1-propanol 
• 144024-34-0 (R)-(-)-3-<1-(4-methylphenyl)sulfonyl-4-indolyloxy>-1-<(4-methylphenyl)sulfonyloxy>-2-propanol 

Relevant articles and documents

Preparation of alkyl-substituted indoles in the benzene portion. Part 8. Improved practical synthesis of 4,4-dialkoxy-1-(1-arylsulfonyl-3-pyrrolyl)-1-butanone and 4-(1-arylsulfonyl-3-pyrrolyl)-4-oxobutanal, and a novel synthetic procedure for 4-alkoxyindole derivatives

Important precursors (1 and 2) for the synthesis of 4-substituted indole derivatives were readily obtained by acid treatment of a tosylamide (13), which was prepared in a single operation by treatment of 10 with N-tosyl-N',N'-dimethylformamidine (TsN=CHNMe2). Compound (10) was effectively synthesized from nitromethane and acrolein by way of a nitro compound (15). A novel indole formation reaction from the tosyl-amide (13) to gain short access to 4-alkoxyindoles, such as 16, 17, 19, and 21 is presented.