144036-36-2

Usage

Structure

Contains a chromene ring with a carbonitrile group and an amino group attached.

Functional Groups

Amino Group (NH2): Attached to the chromene ring.
Nitrophenyl Group (NO2): Positioned at the 4th position of the chromene ring.
Ketone Group (C=O): Present at the 5th position of the chromene ring.
Methyl Groups (CH3): Two methyl groups located at the 7th position.

Pharmacological Potential

Due to its unique structure and functional groups, it may have potential applications in medicinal chemistry for drug development and biological research.

Research Utility

Valuable for further exploration and study in understanding its structural and chemical properties for potential biological activities.

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 126-81-8 dimedone 
• 109-77-3 malononitrile 
• 2826-32-6 3-nitrobenzylidenemalononitrile 
• 2235-08-7 Propargyl nitrile 
• 3471-13-4 dimedone 

Downstream Products

• 353268-85-6 7,7-dimethyl-4-(3-nitro-phenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydro-quinoline-3-carbonitrile 

Relevant academic research and scientific papers

Mg(ClO4)2 as a recyclable catalyst for synthesis of 4H-chromenes

The 4H-choromen derivatives were obtained in excellent yield by three component of an aromatic aldehyde, dimedon and malonitril in the presence catalyst Mg(ClO4)2 as a lewis acid catalyst, in the conditions reflux. The advantage of this method addition to the resuble catalyst, high yield and easy method.

A highly efficient and reusable catalyst for the synthesis of 4H-benzo[b]pyran derivatives

A series of substituted 4H-pyrans derivatives were synthesized by a one-pot, multi-component reaction of aromatic aldehydes, malononitrile, and pyrazolone derivatives or active methylene carbonyl compounds such as dimedone, in the presence of 1,3-dimethyl

Introducing rGO@Fe3O4@Ni as an efficient magnetic nanocatalyst for the synthesis of tetrahydrobenzopyranes via multicomponent coupling reactions of dimedone, malononitrile, and aromatic aldehydes

In this study, the synthesis and characterization of the modified GO and rGO@Fe3O4@Ni composite systems were investigated. Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron mic

The phenyltetrazolethiol-based nickel complex: a versatile catalyst for the synthesis of diverse amidoalkyl naphthols and chromenes

A novel nano-magnetic-supported phenyltetrazolethiol-based Ni complex (Fe3O4@SiO2@ CPTMS@PhenTetThiol@Ni) was synthesized, characterized with different techniques and used as a heterogeneous nano-catalyst in the following

Composite of magnetic carbon quantum dot-supported ionic liquid and Cu-BDC (CCDC no. 687690) MOF: A triple catalytic composite for chemical transformations

A novel magnetic triple composite was synthesized through immobilization of DABCO-based ionic liquid on magnetic carbon quantum dot, followed by conjugation of the resultant compound with a copper-based metal-organic framework (CCDC no. 687690). The as-pr

An eco-friendly innovative halide and metal-free basic ionic liquid catalyzed synthesis of tetrahydrobenzo [b] pyran derivatives in aqueous media: A sustainable protocol

A novel imidazolium-based highly efficient, recoverable, and reusable basic ionic liquid [PEMIM][OH] was synthesized using a very simple approach. This ionic liquid was employed as a catalyst for the multicomponent synthesis of tetrahydrobenzo[b]pyran der

Green synthesis and antibacterial, antifungal activities of 4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives by highly efficient Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanocatalyst

An efficiently, magnetically retrievable Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanoparticles was successfully synthesized and affirmed by several physicochemical characterization tools, such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-disoersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), and power X-ray diffraction. Thereafter, the catalytic performance of this environmentally benign nanocatalyst was investigated in the one-pot multicomponent synthesis of biologically important 2-amino-3-cyano-4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives. The reaction was simply achieved via one-pot three-component reaction of arylaldehydes, malononitrile and dimedone/isatins/methylaceto acetate ethanol at room temperature, with excellent yields and high purity. A new catalytic system, recyclability of reaction medium, little reaction times and excellent yields with easy workup render this protocol more attractive and economically viable.

Biguanide-functionalized hierarchical porous covalent organic frameworks for efficient catalysis of condensation reactions

Covalent organic frameworks (COFs) can be rationally designed with desired physicochemical properties for a far-ranging application in catalytic systems. Herein, a biguanide-functionalized covalent organic framework was designed and prepared via N-alkylat

Introduction of succinimide as a green and sustainable organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b] pyran derivatives

Aim and Objective: In this work, we tried to introduce a non-toxic and stable organic compound named succinimide as a green and efficient organo-catalyst for the promotion of the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives

Magnetized melamine-modified polyacrylonitrile (PAN@melamine/Fe3O4) organometallic nanomaterial: Preparation, characterization, and application as a multifunctional catalyst in the synthesis of bioactive dihydropyrano [2,3-c]pyrazole

An efficient magnetic polymer-based nanomaterial was prepared in three main steps including synthesis of polyacrylonitrile (PAN), modification of PAN with melamine, and magnetization of the PAN@melamine compound by in situ construction of Fe3O