144036-36-2

Basic information

• Product Name: 2-amino-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
• Synonyms: 2-amino-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
• CAS NO: 144036-36-2
• Molecular Formula: C₁₈H₁₇N₃O₄
• Molecular Weight: 339.34528
• Mol File: 144036-36-2.mol
• Article Data: 112

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile(144036-36-2)
• EPA Substance Registry System: 2-amino-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile(144036-36-2)

Safety Data

• Hazardous Substances Data: 144036-36-2(Hazardous Substances Data)

Usage

Structure

Contains a chromene ring with a carbonitrile group and an amino group attached.

Functional Groups

Amino Group (NH2): Attached to the chromene ring.
Nitrophenyl Group (NO2): Positioned at the 4th position of the chromene ring.
Ketone Group (C=O): Present at the 5th position of the chromene ring.
Methyl Groups (CH3): Two methyl groups located at the 7th position.

Pharmacological Potential

Due to its unique structure and functional groups, it may have potential applications in medicinal chemistry for drug development and biological research.

Research Utility

Valuable for further exploration and study in understanding its structural and chemical properties for potential biological activities.

Upstream product

• 2826-32-6 3-nitrobenzylidenemalononitrile 
• 126-81-8 dimedone 
• 3471-13-4 dimedone 
• 99-61-6 3-nitro-benzaldehyde 
• 109-77-3 malononitrile 
• 2235-08-7 Propargyl nitrile 

Downstream Products

• 353268-85-6 7,7-dimethyl-4-(3-nitro-phenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydro-quinoline-3-carbonitrile 

Relevant articles and documents

Mg(ClO4)2 as a recyclable catalyst for synthesis of 4H-chromenes

The 4H-choromen derivatives were obtained in excellent yield by three component of an aromatic aldehyde, dimedon and malonitril in the presence catalyst Mg(ClO4)2 as a lewis acid catalyst, in the conditions reflux. The advantage of this method addition to the resuble catalyst, high yield and easy method.

Introducing rGO@Fe3O4@Ni as an efficient magnetic nanocatalyst for the synthesis of tetrahydrobenzopyranes via multicomponent coupling reactions of dimedone, malononitrile, and aromatic aldehydes

In this study, the synthesis and characterization of the modified GO and rGO@Fe3O4@Ni composite systems were investigated. Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron mic

Composite of magnetic carbon quantum dot-supported ionic liquid and Cu-BDC (CCDC no. 687690) MOF: A triple catalytic composite for chemical transformations

A novel magnetic triple composite was synthesized through immobilization of DABCO-based ionic liquid on magnetic carbon quantum dot, followed by conjugation of the resultant compound with a copper-based metal-organic framework (CCDC no. 687690). The as-pr

Green synthesis and antibacterial, antifungal activities of 4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives by highly efficient Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanocatalyst

An efficiently, magnetically retrievable Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanoparticles was successfully synthesized and affirmed by several physicochemical characterization tools, such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-disoersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), and power X-ray diffraction. Thereafter, the catalytic performance of this environmentally benign nanocatalyst was investigated in the one-pot multicomponent synthesis of biologically important 2-amino-3-cyano-4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives. The reaction was simply achieved via one-pot three-component reaction of arylaldehydes, malononitrile and dimedone/isatins/methylaceto acetate ethanol at room temperature, with excellent yields and high purity. A new catalytic system, recyclability of reaction medium, little reaction times and excellent yields with easy workup render this protocol more attractive and economically viable.