1440509-66-9Relevant articles and documents
Synthesis of internal alkynes through the Pd-catalyzed coupling of heteroaryl halides with terminal alkynes
Lu, Linhua,Yan, Hong,Sun, Peng,Zhu, Yan,Yang, Hailong,Liu, Defu,Rong, Guangwei,Mao, Jincheng
supporting information, p. 1644 - 1648 (2013/04/10)
Sonogashira-type cross-couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature. The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds. The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct functionalization of heterocycles. Sonogashira-type cross-coupling of functionalized heterocyclic halides with terminal alkynes are performed efficiently at room temperature. The catalytic system tolerates a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. The reaction provides an efficient method for the direct functionalization of heterocycles. Copyright