1440529-30-5Relevant articles and documents
Traceless Staudinger acetylation of azides in aqueous buffers
Sowa, Sylwia,Mühlberg, Michaela,Pietrusiewicz, K. Michal,Hackenberger, Christian P.R.
, p. 3465 - 3472 (2013/07/11)
In this paper, we demonstrate the applicability of water-soluble p-dimethylaminoethyl substituted phosphinomethanethiol in acetyl transfer reactions by the traceless Staudinger ligation with unprotected *-azido lysine containing peptides in aqueous buffer systems. Additionally, we present an improved synthesis pathway for the water-soluble phosphinothiol linkers requiring less steps in a comparable overall yield in comparison to previously published protocols.