155887-96-0

Usage

Uses

Used in Pharmaceutical Industry:
m-PEG7-Tos is used as a molecular linker for improving the solubility and bioavailability of drugs. The hydrophilic PEG spacer increases the drug's solubility in aqueous environments, while the tosyl group facilitates nucleophilic substitution reactions, allowing for the attachment of drug molecules to the linker.
Used in Chemical Synthesis:
m-PEG7-Tos is used as a versatile building block in chemical synthesis, particularly for the creation of complex molecular structures. The tosyl group serves as a good leaving group, enabling the formation of new chemical bonds through nucleophilic substitution reactions.
Used in Bioconjugation:
m-PEG7-Tos is used as a bioconjugation agent, allowing for the covalent attachment of biological molecules, such as proteins or peptides, to other molecules or surfaces. The hydrophilic PEG spacer provides stability and solubility, while the tosyl group enables efficient conjugation through nucleophilic substitution.
Used in Drug Delivery Systems:
m-PEG7-Tos is used as a component in the development of drug delivery systems, where it can help improve the solubility, stability, and targeted delivery of therapeutic agents. The PEG spacer can enhance the circulation time of drug carriers in the body, while the tosyl group can be utilized for the attachment of drug molecules or other functional groups.

Upstream product

• 2615-15-8 pentaethylene glycol 
• 50586-80-6 toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester 
• 111-77-3 2-(2-methoxyethoxy)ethyl alcohol 
• 62921-74-8 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate 
• 112-35-6 triethylene glucol monomethyl ether 
• 23601-40-3 hexaethylene glycol monomethyl ether 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1135950-12-7 5-bromo-1,2,3-tris-(2-[2-(2-(2-[2-(2-methoxyethoxy)ethoxy]ethoxy)ethoxy)ethoxy]ethoxy)benzene 
• 1338602-87-1 C₃₄H₆₀O₁₆ 
• 1279100-21-8 C₄₇H₈₆O₂₃ 
• 1338602-91-7 C₅₂H₈₈O₂₄ 
• 1338602-94-0 C₅₆H₉₀N₂O₂₅ 
• 897672-22-9 (S,S)-1,2-bis[5-(4-{2-[2-(2-{2-[2-(2-{2-methoxyethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]-1-methylethoxy}phenyl)-2-methylthiophen-3-yl]perfluorocyclopentene 
• 897672-21-8 1,2-bis[5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophen-3-yl]perfluorocyclopentene 
• 897672-29-6 (S)-3-bromo-5-[4-(2-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-1-methylethoxy)phenyl]-2-methylthiophene 
• 897672-25-2 3-bromo-5-(4-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}phenyl)-2-methylthiophene 
• 897672-27-4 (S)-toluene-4-sulfonic acid 2-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-1-methylethyl ester 
• 897672-28-5 (S)-p-iodo-(2-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}propoxy)benzene 
• 897672-24-1 p-iodo-{2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}benzene 

Relevant academic research and scientific papers

Straightforward synthesis of fluorinated amphiphilic thiols

C8-perfluoroalkyl thiols bearing a polyoxyethylene chain of variable length were prepared in good yields following a straightforward synthetic strategy. These thiols are soluble in organic solvents of different polarities from chloroform to methanol. The thiol with a PEG550 chain shows very good solubility in water. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Enzymatic synthesis of organic-polymer-grafted DNA

To create bioorganic hybrid materials, interdisciplinary work in the fields of chemistry, biology and materials science is conducted. DNA block copolymers are promising hybrid materials due to the combination of properties intrinsic to both the polymer an

Alkaline earth metal-sensing anthracene fluorophore-hosts

Novel anthracene fluorophore-hosts 1-4, bonding through an ester or ether linkage to a crown ether or polyether side-arm, have been synthesized. Addition of an alkaline earth metal cation to a host solution causes a unique fluorescence intensity change. That is, the hosts bonding through an ester linkage, compounds 1 and 3, give fluorescence quenching, whereas the hosts bonding through an ether linkage, compounds 2 and 4, give fluorescence enhancement. The host having a crown ether side-arm, compound 2, recognises calcium cations more strongly than barium cations, in contrast to the host having a polyether side-arm, compound 4, which prefers barium cations to calcium cations.

Micelle/monomer control over the membrane-disrupting properties of an amphiphilic antibiotic

A homologous series of amphotericin B-oligo(ethylene glycol) conjugates has been synthesized, via condensation of the carboxylic acid group of amphotericin B with oligo(ethylene glycol)-substituted amines [NH2(CH2-CH2O)(n)CH3, where n = 1, 6, 15], and examined with respect to their aggregation properties and their ability to disrupt the membrane integrity of Candida albicans and human red blood cells. Incremental increase in the size of the oligo(ethylene glycol) moiety leads to a significant increase in the critical micelle concentration of the macrolide and to a corresponding increase in the concentration that is required for hemolysis. In sharp contrast, the same increase in oligo(ethylene glycol) size affords only a modest reduction in antifungal activity; the net result is a separation of antifungal and hemolytic activity. These results clearly highlight the need for taking into account the aggregation properties of membrane-disrupting antibiotics with respect to target recognition and specificity and also with regard to rational molecular design.

Targeting G Protein-Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor

The A3 adenosine receptor (AR) is a G protein-coupled receptor (GPCR) overexpressed in the membrane of specific cancer cells. Thus, the development of nanosystems targeting this receptor could be a strategy to both treat and diagnose cancer. Iron-filled carbon nanotubes (CNTs) are an optimal platform for theranostic purposes, and the use of a magnetic field can be exploited for cancer magnetic cell sorting and thermal therapy. In this work, we have conjugated an A3AR ligand on the surface of iron-filled CNTs with the aim of targeting cells overexpressing A3ARs. In particular, two conjugates bearing PEG linkers of different length were designed. A docking analysis of A3AR showed that neither CNT nor linker interferes with ligand binding to the receptor; this was confirmed by in vitro preliminary radioligand competition assays on A3AR. Encouraged by this result, magnetic cell sorting was applied to a mixture of cells overexpressing or not the A3AR in which our compound displayed indiscriminate binding to all cells. Despite this, it is the first time that a GPCR ligand has been anchored to a magnetic nanosystem, thus it opens the door to new applications for cancer treatment.

Compound, preparation method thereof and application of compound as fluorescent probe for detecting near-infrared two-region of acetoaldehyde (by machine translation)

The invention provides a compound, a preparation method thereof and application of the compound as an acetone aldehyde near-infrared two-zone fluorescent probe. The compound has the structure shown by general I and has good response to propionaldehyde. ,

Self-Assembly and Molecular Recognition in Water: Tubular Stacking and Guest-Templated Discrete Assembly of Water-Soluble, Shape-Persistent Macrocycles

Supramolecular chemistry in aqueous media is an area with great fundamental and practical significance. To examine the role of multiple noncovalent interactions in controlled assembling and binding behavior in water, the self-association of five water-soluble hexakis(m-phenylene ethynylene) (m-PE) macrocycles, along with the molecular recognition behavior of the resultant assemblies, is investigated with UV-vis, fluorescence, CD, and NMR spectroscopy, mass spectrometry, and computational studies. In contrast to their different extents of self-aggregation in organic solvents, all five macrocycles remain aggregated in water at concentrations down to the micromolar (μM) range. CD spectroscopy reveals that 1-F6 and 1-H6, two macrocycles carrying chiral side chains and capable of H-bonded self-association, assemble into tubular stacks. The tubular stacks serve as supramolecular hosts in water, as exemplified by the interaction of macrocycles 1-H6 and 2-H6 and guests G1 through G4, each having a rod-like oligo(p-phenylene ethynylene) (p-PE) segment flanked by two hydrophilic chains. Fluorescence and 1H NMR spectroscopy revealed the formation of kinetically stable, discrete assemblies upon mixing 2-H6 and a guest. The binding stoichiometry, determined with fluorescence, 1H NMR, and ESI-MS, reveals that the discrete assemblies are novel pseudorotaxanes, each containing a pair of identical guest molecules encased by a tubular stack. The two guest molecules define the number of macrocyclic molecules that comprise the host, which curbs the "infinite" stack growth, resulting in a tubular stack with a cylindrical pore tailoring the length of the p-PE segment of the bound guests. Each complex is stabilized by the action of multiple noncovalent forces including aromatic stacking, side-chain H-bonding, and van der Waals interactions. Thus, the interplay of multiple noncovalent forces aligns the molecules of macrocycles 1 and 2 into tubular stacks with cylindrical inner pores that, upon binding rod-like guests, lead to tight, discrete, and well-ordered tubular assemblies that are unprecedented in water.

Hydrophilic metal-organic polyhedra, preparation method thereof and gas separation membrane comprising the same

The present invention relates to a hydrophilic metal-organic polyhedron, a production method thereof, and a gas separator including the same. More specifically, by producing the hydrophilic metal-organic polyhedron containing a polyethylene oxide-based organic ligand and mixing the same with a crosslinked polyethylene oxide polymer, the hydrophilic metal-organic polyhedron can be applied as a gas separator which exhibits a high CO_2/N_2 permeation selectivity.COPYRIGHT KIPO 2018

CARBON MONOXIDE-RELEASING MOLECULES AND THERAPEUTIC APPLICATIONS THEREOF

Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.

AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.