144067-46-9

Upstream product

• 217076-36-3 (E)-6-Bromo-1-[5-(1-methoxymethoxy-allyl)-2,6,6-trimethyl-cyclohex-1-enyl]-hex-2-en-1-ol 
• 216978-11-9 (E)-6-Bromo-1-[5-(1-methoxymethoxy-allyl)-2,6,6-trimethyl-cyclohex-1-enyl]-hex-2-en-1-one 
• 216978-74-4 Acetic acid 5-(1-methoxymethoxy-allyl)-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 
• 216978-59-5 5-(1-Methoxymethoxy-allyl)-2,6,6-trimethyl-cyclohex-1-enecarbaldehyde 
• 216978-58-4 [5-(1-Methoxymethoxy-allyl)-2,6,6-trimethyl-cyclohex-1-enyl]-methanol 
• 216978-73-3 1-Acetoxymethyl-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene 
• 144066-82-0 Acetic acid 2-isopropenyl-3-methyl-but-2-enyl ester 
• 144067-40-3 Acetic acid 5-formyl-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 
• 144067-41-4 1-Hydroxymethyl-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene 
• 144067-42-5 1-Formyl-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene 
• 52385-60-1 (3-methyl-2-methylethenyl)-2-buten-1-ol 
• 99978-27-5 2-(α-hydroxy-isopropyl)-3-methyl-crotonic acid ethyl ester 
• 100144-50-1 2-isopropenyl-3-methyl-crotonic acid methyl ester 
• 4412-05-9 2-isopropenyl-3-methyl-crotonic acid 

Downstream Products

• 144067-39-0 1-((E)-6-Iodo-1-oxohex-2-enyl)-2,6,6-trimethyl-5-(1-oxoprop-2-enyl)cyclohex-1-ene 

Relevant academic research and scientific papers

A tandem radical macrocyclisation-transannular cyclisation approach towards the taxanes

Separate treatment of the iodotrienedione 19 and the iododienynedione 38 with Bu3SnH-AIBN produces the corresponding taxane ring systems 25 (25-30%) and 56 (50-60%) respectively by way of tandem radical macrocyclisation-radical transannular cyc

A tandem radical macrocyclisation - Radical transannulation strategy to the taxane ring system

Treatment of the iodo-trienone (8 b) with tri-n-butyltin hydride in the presence of AIBN is shown to produce the taxane ring system (11) by way of a tandem radical macrocyclisation - radical transannulation sequence, i.e. (8 b) → (9) → (11) (cf. Scheme 1)