144068-36-0

Upstream product

• 144068-34-8 2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester 
• 93489-72-6 [1R-[1β,[αS*,βS*],3aα,4aβ,7aβ]]-octahydro-β,7a-dimethyl-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-α-ethenyl-1H-indene-1-ethanol 
• 144068-37-1 (3R,5S)-5-{(1R,2S)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-1-iodo-propyl}-3-(4-methoxy-benzyloxy)-3-methyl-dihydro-furan-2-one 

Downstream Products

• 144125-15-5 (3R,5R)-5-{(1S,2S)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-1-iodo-propyl}-3-(4-methoxy-benzyloxy)-3-methyl-dihydro-furan-2-one 
• 144068-37-1 (3R,5S)-5-{(1R,2S)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-1-iodo-propyl}-3-(4-methoxy-benzyloxy)-3-methyl-dihydro-furan-2-one 
• 144068-42-8 (3R,5S)-5-{(R)-2-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-propyl}-3-(4-methoxy-benzyloxy)-3-methyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

A Practical Convergent Route to (23S,25R)-1α,25-Dihydroxyvitamin D3 26,23-Lactone

The Ireland-Claisen rearrangement of the lactate 8, prepared from the Inhoffen-Lythgoe diol 5, followed by iodolactonisation allowed easy access to the C-D-ring fragment 4, from which a novel convergent synthesis of (23S,25R)-1α,25-dihydroxyvitamin D