1440779-46-3

Upstream product

• 63069-48-7 p-chloro-o-iodoaniline 
• 692-51-3 (E)-trimethyl(3,3,3-trifluoroprop-1-en-1-yl)silane 

Downstream Products

• 1440779-54-3 6-chloro-2-phenyl-3-(trifluoromethyl)quinoline 
• 1440779-62-3 6-chloro-2-(4-methoxyphenyl)-3-(trifluoromethyl)quinoline 

Relevant academic research and scientific papers

Synthesis of 2-aryl-3-trifluoromethylquinolines using (E)-trimethyl(3,3,3- trifluoroprop-1-enyl)silane

The Hiyama cross-coupling reaction of (E)-trimethyl(3,3,3-trifluoroprop-1- enyl)silane (1) with 2-iodoaniline (2) proceeded without any protection of the amino group. The coordination of copper(II) fluoride to 2,2′-bipyridyl provided the fluoride source required to trigger this reaction, affording (E)-2-(3,3,3-trifluoroprop-1-enyl)aniline (3). In the presence of a stoichiometric amount of [Cu(OTf)]2·C6H 6, the treatment of 3 with an aryl aldehyde at 200 C provided the 2-aryl-3-trifluoromethylquinoline (4) via the oxidative cyclization of an in situ-generated imine substructure.