1440858-69-4

Basic information

• Product Name: 1-(4-hydroxyphenyl)-3-(1H-imidazol-1-yl)-1-propanone
• Synonyms: 1-(4-hydroxyphenyl)-3-(1H-imidazol-1-yl)-1-propanone
• CAS NO: 1440858-69-4
• Molecular Weight: 216.239
• Mol File: 1440858-69-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-hydroxyphenyl)-3-(1H-imidazol-1-yl)-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-hydroxyphenyl)-3-(1H-imidazol-1-yl)-1-propanone(1440858-69-4)
• EPA Substance Registry System: 1-(4-hydroxyphenyl)-3-(1H-imidazol-1-yl)-1-propanone(1440858-69-4)

Safety Data

• Hazardous Substances Data: 1440858-69-4(Hazardous Substances Data)

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 288-32-4 1H-imidazole 
• 2125-51-1 3-dimethylamino-1-(p-hydroxyphenyl)-1-propanone hydrochloride 

Relevant articles and documents

A novel antifungal agent with broad spectrum: 1-(4-Biphenylyl)-3-(1H- imidazol-1-yl)-1-propanone

A series of (1-substituted aryl)-3-(1H-imidazol-1-yl)-1-propanones was synthesized through the N-alkylation of imidazole with 3-dimethylamino-1- (substituted aryl)-1-propanone hydrochlorides (ketonic Mannich bases). A second series of N1-substituted imidazoles was obtained by the reduction of the carbonyl function of the imidazole-ketones in the previous series by means of NaBH4. All of the compounds were evaluated for antifungal activity against 16 strains of Candida, and 3-(1H-imidazol-1-yl)-1-(4-biphenylyl)-1- propanone emerged as a broad-spectrum antifungal agent. Several 3-(1H-imidazol-1-yl)-1-(2′-(substituted benzyl)oxyphenyl)-1-propanones were also active towards Candida kefyr. Copyright