2125-51-1Relevant articles and documents
Macrocyclic Metal Complexes Bearing Rigid Polyaromatic Ligands: Synthesis and Catalytic Activity
Yamamoto, Koji,Higuchi, Kazuki,Ogawa, Masahiro,Sogawa, Hiromitsu,Kuwata, Shigeki,Hayashi, Yoshihiro,Kawauchi, Susumu,Takata, Toshikazu
, p. 356 - 359 (2020)
We synthesised palladium and platinum complexes possessing cyclic and acyclic pincer-type polyaromatic ligands and investigated their structural effect on the catalysis. The pincer-type bis(6-arylpyridin-2-yl)benzene skeleton was constructed via Kr?hnke pyridine synthesis under transition metal-free conditions on gram-scale quantity. Ligand structure significantly influenced catalytic activity toward the platinum-catalysed hydrosilylation of diphenyl acetylenes, despite the ligand-independence of the conformations and electronic properties of these complexes.
A novel antifungal agent with broad spectrum: 1-(4-Biphenylyl)-3-(1H- imidazol-1-yl)-1-propanone
Roman, Gheorghe,Mare?, Mihai,Nǎstasǎ, Valentin
, p. 110 - 118 (2013/04/10)
A series of (1-substituted aryl)-3-(1H-imidazol-1-yl)-1-propanones was synthesized through the N-alkylation of imidazole with 3-dimethylamino-1- (substituted aryl)-1-propanone hydrochlorides (ketonic Mannich bases). A second series of N1-substituted imidazoles was obtained by the reduction of the carbonyl function of the imidazole-ketones in the previous series by means of NaBH4. All of the compounds were evaluated for antifungal activity against 16 strains of Candida, and 3-(1H-imidazol-1-yl)-1-(4-biphenylyl)-1- propanone emerged as a broad-spectrum antifungal agent. Several 3-(1H-imidazol-1-yl)-1-(2′-(substituted benzyl)oxyphenyl)-1-propanones were also active towards Candida kefyr. Copyright
PYRAZOLE INHIBITORS OF WNT SIGNALING
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Page/Page column 33, (2009/01/20)
The invention provides inhibitors of Wnt signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein R1 to R7 and Z are as defined herein.