144088-23-3Relevant academic research and scientific papers
Effect of charge and surface area on the cytotoxicity of cationic metallointercalation reagents
Edwards, Gavin L.,Black, David St.C.,Deacon, Glen B.,Wakelin, Laurence P.G.
, p. 969 - 979 (2007/10/03)
Reaction of a series of nitrogen donor ligands (1-phenylpyrazoles, 2-phenylpyridine, benzo[h]quinoline, 1-(2′-pyridyl)indole, 1-phenylindazole, and 2-phenylindazole) with palladium(II) and platinum(II) salts gave complexes where ortho-metallation had occurred resulting in bidentate binding to the metal centres through N and C atoms. These cyclometallated products were isolated as μ-chloro dimers. Subsequent treatment of these μ-chloro dimers with chelating diamines such as 1,2-ethanediamine converted them into 14 cationic (1+) complexes. Analogous coordination mixed ligand complexes (charge 2+) were prepared by reaction of dichloro(1,2-ethanediamine-N, N′)palladium(II) with aromatic diamines such as 2-(1′-pyrazolyl) pyridine, 2,2′-bipyridine, and 1,10-phenanthroline. The complexes exhibited growth inhibitory activity against L1210 mouse leukaemia cells in vitro over a wide concentration range; in general, the cyclometallated complexes were more active than the mixed ligand complexes, although one cyclometallated organoplatinum complex was less active than the mixed ligand analogue. Substitution around the periphery of the aromatic ligands also resulted in increased activity. One complex, derived from 1-(2′-pyridyl) indole, was tested in vivo and showed no significant antitumour inhibition against P388 leukaemia at doses below toxic levels.
Palladium(II) coordination and cyclometallated complexes derived from 3- and 5-aryl-substituted pyrazoles
Alonso, M. T.,Juanes, O.,Mendoza, J. de,Rodriguez-Ubis, J. C.
, p. 335 - 347 (2007/10/02)
Palladium(II) coordination complexes of nine 3- or 5-arylpyrazoles (phenyl, 2-bromophenyl, or 3-methoxyphenyl), as well as of 3,5-diphenylpyrazole, are reported.A cis-trans mixture of isomers is found in the case of 3-aryl-1-methylpyrazoles, the cis-isomers being transformed into trans by heating.Only trans isomers are isolated with the other ligands.Cyclopalladation of 3-aryl-1-methylpyrazoles can be performed with palladium(II) acetate, and the resultant μ-acetate bridged dimers can be transformed into μ-chloro bridged dimers or acetylacetonate monomers.The structures of the complexes have been characterized by 1H- and 13C-NMR spectroscopy.
