19311-79-6

Basic information

• Product Name: 1-Methyl-3,5-diphenylpyrazole
• Synonyms: 1-Methyl-3,5-diphenylpyrazole
• CAS NO: 19311-79-6
• Molecular Formula: C₁₆H₁₄N₂
• Molecular Weight: 234.2958
• Mol File: 19311-79-6.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 387.5 °C at 760 mmHg
• Flash Point: 188.2 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 7.32E-06mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 1-Methyl-3,5-diphenylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3,5-diphenylpyrazole(19311-79-6)
• EPA Substance Registry System: 1-Methyl-3,5-diphenylpyrazole(19311-79-6)

Safety Data

• Hazardous Substances Data: 19311-79-6(Hazardous Substances Data)

Usage

General Description

1-Methyl-3,5-diphenylpyrazole is a chemical compound with the molecular formula C17H16N2. It is a pyrazole derivative, which is a class of organic compounds containing a five-membered ring with two nitrogen atoms. 1-Methyl-3,5-diphenylpyrazole is commonly used in the field of pharmaceutical research and development, as well as in the synthesis of other organic compounds. It has also been studied for its potential biological activities, including its anti-inflammatory and analgesic properties. Additionally, 1-Methyl-3,5-diphenylpyrazole has shown promise in the field of materials science, particularly in the area of organic electronics and optoelectronic devices. Overall, this compound has a wide range of potential applications and is the subject of ongoing research in various fields.

InChI:InChI=1/C16H14N2/c1-18-16(14-10-6-3-7-11-14)12-15(17-18)13-8-4-2-5-9-13/h2-12H,1H3

Upstream product

• 1145-01-3 3,5-Diphenylpyrazole 
• 74-88-4 methyl iodide 
• 26105-53-3 2-methyl-4,6-diphenylpyrylium iodide 
• 94-41-7 benzalacetophenone 
• 60-34-4 methylhydrazine 
• 90145-13-4 N'-<α-bromobenzylidene>-N-methylhydrazinium bromide 
• 536-74-3 phenylacetylene 
• 29100-31-0 1-methyl-3,5,7-triphenyl-1,2(1H)-diazepine 
• 14947-61-6 boron difluoride 1,3-diphenylpropane-1,3-dionate 
• 26429-56-1 1,2-dimethyl-3,5-diphenylpyrazolium iodide 
• 591-50-4 iodobenzene 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 1188116-65-5 5-bromo-1-methyl-3-phenyl-1H-pyrazole 
• 98-80-6 phenylboronic acid 

Downstream Products

• 43222-48-6 1,2-dimethyl-3,5-diphenyl-1H-pyrazolium methyl sulphate 
• 43222-46-4 1,2-dimethyl-3,5-diphenylpyrazolium p-toluene sulfonate 
• 144088-23-3 trans-dichloro{bis(3,5-diphenyl-1-methylpyrazole)}palladium(II) 
• 144088-23-3 cis-dichloro{bis(3,5-diphenyl-1-methylpyrazole)}palladium(II) 
• 26429-56-1 1,2-dimethyl-3,5-diphenylpyrazolium iodide 
• 76439-40-2 1-ethyl-3,5-diphenyl-1H-pyrazole 
• 88070-48-8 N-methylbenzamide 
• 43222-53-3 1-ethyl-2-methyl-3,5-diphenylpyrazolium ethyl sulfate 

Relevant articles and documents

Preparation method of pyrazole derivative (by machine translation)

The preparation method comprises the following steps: mixing an alkyne propyl alcohol derivative, a halogen source, an acid and a solvent, heating and reacting, and reacting to Meyer - Schuster generate the pyrazole derivative. Compared with the prior art, the preparation method disclosed by the invention has 91% the advantages of maximum yield, simple operation, mild conditions, high conversion rate, few byproducts and the like, and provides a brand-new synthetic method for construction of pyrazole compounds. (by machine translation)

Nucleophilic ring-opening reactions of trans-2-aroyl-3-aryl-cyclopropane-1,1-dicarboxylates with hydrazines

trans-2-Aroyl-3-aryl-cyclopropane-1,1-dicarboxylates when treated with arylhydrazines in refluxing EtOH gave dihydropyrazoles, whereas with hydrazines in refluxing AcOH, they formed cyclopropane-fused pyridazinones. Although in both cases the corresponding hydrazones are formed initially, the former case involves a subsequent 5-exo-tet nucleophilic ring-opening, and the later, a 6-exo-trig nucleophilic attack by the other hydrazone nitrogen. The products are obtained in moderate to excellent yields with complete regio-and diastereoselectivity.

Radical Addition of Hydrazones by α-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis

A novel efficient tandem reaction of hydrazones and α-bromo ketones is reported for the preparation of 1,3,5-trisubstituted pyrazoles by visible light catalysis. In this system, the monosubstituted hydrazones show wonderful reaction activity with alkyl radicals, generated from α-bromo ketones. A radical addition followed by intramolecular cyclization affords the important pyrazole skeleton in good to excellent yields. This efficient strategy under mild conditions with wide group tolerance provides a potential approach to the 1,3,5-trisubstituted pyrazoles.