1440972-49-5Relevant academic research and scientific papers
Total synthesis of aplyronine C
Paterson, Ian,Fink, Sarah J.,Lee, Lydia Y. W.,Atkinson, Stephen J.,Blakey, Simon B.
, p. 3118 - 3121 (2013)
A highly stereocontrolled total synthesis of the cytotoxic marine macrolide aplyronine C is described. The route exploits aldol methodology to install the requisite stereochemistry and features a crucial boron-mediated aldol coupling of an N-vinylformamide-bearing methyl ketone with a macrocyclic aldehyde to introduce the full side chain. The synthesis of two novel C21-C34 side chain analogs is also reported.
