144101-41-7

Basic information

• Product Name: 1-(2-HYDROXY-ETHYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE
• Synonyms: 1-(2-HYDROXY-ETHYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE;1-(2-HYDROXYETHYL)-6-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE
• CAS NO: 144101-41-7
• Molecular Formula: C7H10N2O3
• Molecular Weight: 170.17
• Mol File: 144101-41-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-HYDROXY-ETHYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-HYDROXY-ETHYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE(144101-41-7)
• EPA Substance Registry System: 1-(2-HYDROXY-ETHYL)-6-METHYL-1H-PYRIMIDINE-2,4-DIONE(144101-41-7)

Safety Data

• Hazardous Substances Data: 144101-41-7(Hazardous Substances Data)

Upstream product

• 141-43-5 ethanolamine 
• 2911-21-9 2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine 
• 91114-97-5 5-acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-dione 

Relevant articles and documents

A Convenient Approach to meso -Uracil-4,4-Difluoro-4-bora-3a, 4a-diaza- s -indacene Derivatives

An effective and convenient protocol for the synthesis of 1-substituted uracil-6-carbaldehyde derivatives has been developed. A three-step sequence permits the preparation of uracil-6-carbaldehydes with various substituents at the N-1 in large quantities by using low-cost precursors. The aldehyde-functionalized uracils served as useful precursors for the preparation of meso-(1-substituted 6-uracil)-derivatives of 4,4-difluoro-4-bora-3a,4a-diaza- s -indacene (BODIPY). In this way, regioselectively functionalized BODIPYs with a direct connection to a nucleobase were prepared in yields of 30-45%. MALDI-TOF mass spectrometry, NMR, UV/vis absorption, and steady-state and time-resolved fluorescence spectroscopies were used to characterize the structures and the spectroscopic/photophysical properties of the resultant dyes.

Azines and azoles: CXXII. New regioselective synthesis of 1-substituted 6-alkyluracils

Readily available 5-acyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-diones with primary alkyl- and arylamines in mild conditions (boiling in propan-2-ol) to give Schiff bases. In more rigid conditions (boiling in DMF), the reaction is accompanied by COS liberation and provides 1-substituted 6-alkyluracils. This previously unknown reaction possesses a considerable synthetic potential and can be considered as a new, general, and regioselective synthetic approach to 1-substituted 6-alkyluracils.