91114-97-5Relevant articles and documents
Study of Antioxidant Activity of New Compounds with 1,3-Thiazin-2,6-Dione and Pyrrolidine Fragments
Berberova, N. T.,Kolyada, M. N.,Osipova, A. D.,Osipova, V. P.,Polovinkina, M. A.,Velikorodov, A. V.
, p. 188 - 191 (2022/02/22)
Abstract: Antioxidant activity of new compounds with 1,3-diazin-2,6-dione and pyrrolidine fragments in comparison with 2,6-di-tert-butyl-4-mercaptophenol has been studied in the model system of adrenaline autooxidation in alkaline medium in DPPH, NBT, and CUPRAC tests. In the series of studied compounds, a leader has been revealed, which shows moderate antiradical activity toward DPPH radical, prevents accumulation of toxic products of adrenaline quinoid oxidation, and exhibits higher efficiency as one-electron Cu2+ reducing reagent as compared with known antioxidants, trolox and 2,6-di-tert-butyl-4-mercaptophenol.
One-pot two-step synthesis of fused thiazinofuranone linked geminal bis 1,2,3-triazole hybrids and their in vitro cytotoxic screening
Mupparapu, Praveen Kumar,Thirukovela, Narasimha Swamy,Gullapelli, Sadanandam,Kurra, Mohan,Gali, Srinivas,Vaddiraju, Namratha
, p. 1379 - 1387 (2021/03/03)
In this study, a series of novel geminal bis 1,2,3-triazoles linked to 2H-furo[2,3-d][1,3]thiazine-2,4,5(1H,6H)-trione (3a-3m) were prepared in one pot starting from 5-Acetyl-4-Hydroxy-1,3-thiazine-2,6-dione (1) to 6,6-diazido-2H-furo[2,3-d][1,3]thiazine-2,4,5(1H,6H)-trione (2) followed by Cu(I)-catalyzed azide-alkyne cycloaddition. The synthesized compounds were further explored for in vitro cytotoxic activity against PC3, A549, MCF-7, and HeLa cell lines and results revealed that the five compounds 3c, 3d, 3g, 3l, and 3m have displayed comparable in vitro cytotoxic activity with the standard drug Etoposide.
Synthesis of New Derivatives of 5-Acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione
Velikorodov,Zukhayrayeva,Osipova,Polovinkina
, p. 1884 - 1889 (2020/01/31)
5-Acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione reacted with cyclohexyl and benzyl (4-aminophenyl)carbamates in boiling ethanol in the presence of a catalytic amount of glacial acetic acid to give the corresponding Schiff bases, cyclohexyl and benzyl (4-
NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS
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Paragraph 222, (2016/08/23)
The invention relates to novel heteroaryl and heterocycle compounds of formula I and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.
NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS
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Page/Page column 103, (2014/02/16)
The invention relates to novel heteroaryl and heterocycle compounds and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3k and for treating inflammatory and autoimmune disorders diseases and cancer.
NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITION AND METHODS THEREOF
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Page/Page column 130, (2014/02/16)
Disclosed are novel heteroaryl and heterocycle compounds of formula I-1, I-2 or I-3 and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.
NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS
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Page/Page column 131, (2014/02/16)
Provided are novel heteroaryl and heterocycle compounds of formula (I-1), (I-2) or (I-3) and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune disorders diseases and cancer.
Azines and azoles: CXXV. New regioselective synthesis of 1-amino-6-methyluracils
Yuskovets,Ivin,Kirillova
, p. 2150 - 2161 (2008/09/17)
Readily accessible 5-acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-dione reacts with substituted hydrazines and carboxylic acid hydrazides under mild conditions to give the corresponding hydrazones. Under severe conditions (heating in boiling dimethylformamide) the reaction is accompanied by extrusion of COS with formation of substituted 1-amino-6-methyluracils. Reactions of 5-acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-dione with monosubstituted alkyl-and arylhydrazines take different pathways, depending on the conditions. Heating of equimolar mixtures of the reactants in ethanol or propan-1-ol leads to the formation of 2-substituted 5-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4- carboxamides rather than 1-amino-6-methyluracil derivatives.
TROMBIN INHIBITING 2,4-DIOXO-3,4-DIHYDROPYRIMIDINE DERIVATIVES
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Page/Page column 82-83, (2010/11/25)
There is provided a compound of formula I wherein R1 to R5, A, G, L and X have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as
Azines and azoles: CXXIII. Three-component condensation of 5-acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-dione with o-phenylenediamine and carbonyl compounds as a convenient synthesis of substituted 1,5-benzodiazepines
Yuskovets,Uankpo, Berzhe,Ivin
, p. 801 - 813 (2008/02/02)
Readily accessible 5-acetyl-4-hydroxy-3,6-dihydro-2H-1,3-thiazine-2,6-dione reacted with an equimolar amount of o-phenylenediamine under mild conditions (propan-2-ol, 5 min, reflux) to give the corresponding Schiff base. Reactions of the latter with aldeh
