1441119-09-0Relevant articles and documents
Synthesis of 4-amino-2,6-diaryl-5-cyanopyrimidines as antimicrobial agents
do Monte, Zenaide Severina,Monteiro, Maria Renata Leite,Borba, Camila Beatriz Atanásio,de Gusm?o, Norma Buarque,Falc?o, Emerson Peter da Silva,Silva, Ricardo Oliveira,Srivastava, Rajendra M.,de Melo, Sebasti?o José
, p. 983 - 991 (2016)
This article describes an efficient and facile synthesis of 11 2,4,6-trisubstituted 5-cyanopyrimidines starting from meta- and para-substituted 2-cyanocinnamonitriles and arylamidines. The synthesized heterocycles, 3a–k, were characterized by infrared (IR
Synthesis, antitrypanosomal activity and molecular docking studies of pyrimidine derivatives
de Melo, Sebasti?o José,do Monte, Zenaide Severina,da Silva Santos, Aline Caroline,Silva, Ana Catarina Cristov?o,Ferreira, Luiz Felipe Gomes Rebello,Hernandes, Marcelo Zaldini,Silva, Ricardo Oliveira,da Silva Falc?o, Emerson Peter,Brelaz-de-Castro, Maria Carolina Accioly,Srivastava, Rajendra M.,Pereira, Valeria Rêgo Alves
, p. 2512 - 2522 (2018/11/10)
This publication describes the synthesis of 28 pyrimidine derivatives of which eight are new. Their structures have been verified by spectroscopic techniques (IR, H1, C13 NMR data). The mass spectral analysis gave correctly the elemental compositions of a
A New Facile, High Yielding and Efficient Protocol for the Synthesis of Novel 4-Phenylsulfonamido-6-Aryl-2-Phenylpyrimidine-5-Carbonitrile Derivatives
Aryan, Reza,Nojavan, Masoomeh,Sadeghi, Fatemeh
, p. 1994 - 2004 (2015/12/12)
A series of novel 4-phenylsulfonamido-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives have been synthesized through a two-step process. This protocol includes a facile surfactant-mediated methodology for the synthesis of 4-amino-6-aryl-2-phenylpyrimi
A novel and efficient synthesis of pyrazolo[3,4-d]pyrimidine derivatives and the study of their anti-bacterial activity
Rostamizadeh, Shahnaz,Nojavan, Masoomeh,Aryan, Reza,Sadeghian, Hamid,Davoodnejad, Mahdieh
, p. 629 - 632 (2013/07/27)
In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot, three-component reaction of an aldehyde, malononitrile and benzamidine hydrochloride, in the presence of magnetic nano Fe3O4 particles as a catalyst under solvent-free conditions. 3-Amino-6-aryl-2-phenylpyrazolo[3,4-d]pyrimidine derivatives were prepared through an efficient and environmentally friendly reaction between 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives and hydrazine hydrate and their antibacterial activity has been evaluated.
A facile synthesis of new pyrazolo[3,4-d]pyrimidine derivatives via a one-pot four-component reaction with sodium acetate supported on basic alumina as promoter
Rostamizadeh, Shahnaz,Nojavan, Masoomeh,Aryan, Reza,Isapoor, Elyass
, p. 2267 - 2275 (2014/01/06)
An efficient one-pot procedure for the synthesis of 3-amino-6-aryl-2- phenylpyrazolo[3,4-d]pyrimidine derivatives, through the reaction of aldehydes, malononitrile, benzamidine hydrochloride, and hydrazine hydrate in the presence of basic alumina-supported sodium acetate (AcONa/Al2O3) under reflux conditions, is reported. This protocol has some advantages, including the use of a simple and one-pot synthetic approach to attain pyrazolo[3,4-d]pyrimidine directly from four readily available starting materials, simple workup, high overall yields of the products, and the simultaneous conversion of a NO2 to an amino group, offering an opportunity to synthesize more complex structures. Copyright
