1441180-38-6

Basic information

• Product Name: 3-ethoxy-1-(2-methoxyphenyl)-1-phenylpropyl-2-yn-1-ol
• Synonyms: 3-ethoxy-1-(2-methoxyphenyl)-1-phenylpropyl-2-yn-1-ol
• CAS NO: 1441180-38-6
• Molecular Weight: 282.339
• Mol File: 1441180-38-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-ethoxy-1-(2-methoxyphenyl)-1-phenylpropyl-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethoxy-1-(2-methoxyphenyl)-1-phenylpropyl-2-yn-1-ol(1441180-38-6)
• EPA Substance Registry System: 3-ethoxy-1-(2-methoxyphenyl)-1-phenylpropyl-2-yn-1-ol(1441180-38-6)

Safety Data

• Hazardous Substances Data: 1441180-38-6(Hazardous Substances Data)

Upstream product

• 2553-04-0 ortho-methoxybenzophenone 
• 927-80-0 1-ethoxyacetylene 

Downstream Products

• 1441181-09-4 3-iodo-4-phenyl-2H-1-benzopyran-2-one 

Relevant articles and documents

Hypervalent iodine compound containing heterocyclic ring as well as preparation method and application thereof

The invention discloses a hypervalent iodine compound containing a heterocyclic ring as well as a preparation method and application thereof. A structure of the compound is shown as a formula (I): theformula (I) is shown in the description, wherein R is selected from hydrogen, halogen, alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, nitryl, cyano, hydroxyl or -COOR'; R' is alkyl or halogenated alkyl; and Het is substituted or non-substituted 1,4-benzopyranone, substituted or non-substituted quinolone, substituted or non-substituted isoquinoline, substituted or non-substituted thiobenzopyranone, substituted or non-substituted coumarin and substituted or non-substituted oxepin. The compound disclosed by the invention is novel in structure and is the hypervalent iodine compound containing the heterocyclic ring; the hypervalent iodine compound is stable in structure and simple in preparation method; and meanwhile, the hypervalent iodine compound has a very good inhibition effect onML-1 and MOLM-13 cells and has an extremely great application prospect on prevention and/or treatment effect on leukemia.

Synthesis of substituted 3-iodocoumarins and 3-iodobutenolides via electrophilic iodocyclization of ethoxyalkyne diols

A convenient and general synthesis of various 4-substituted 3-iodocoumarins and 4,5-disubstituted 3-iodobutenolides is described via an exclusive 6-endo-dig iodocyclization of 3-ethoxy-1-(2-alkoxyphenyl)-2-yn-1-ols and 5-endo-dig iodocyclization of 1-alkoxy-4-ethoxy-3-yn-1,2-diols, respectively. The reaction is carried out under very mild conditions using I2 in CH2Cl2 or toluene at room temperature. Oxygens in OMe and OMOM groups were used as efficient nucleophiles for this intramolecular cyclization to obtain the products in good to excellent yields.