1441224-39-0Relevant articles and documents
OXINDOLE COMPOUNDS, SOLVENT-FREE SYNTHESIS AND USE THEREOF
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Page/Page column 13; 18, (2014/10/18)
The present invention discloses oxindole compounds and a single step, one pot reaction for the the synthesis of oxindole derivates via a solvent free Passerini reaction of isocyanides, isatins and carboxylic acids.
Engaging isatins in solvent-free, sterically congested Passerini reaction
Kaicharla, Trinadh,Yetra, Santhivardhana Reddy,Roy, Tony,Biju, Akkattu T.
supporting information, p. 1608 - 1614 (2013/09/24)
A facile, atom-economic and environmentally-benign protocol for the synthesis of biologically important oxindole derivatives in high yields has been demonstrated by employing isatins as carbonyl compound surrogates in a Passerini reaction carried out under solvent-free conditions. Moreover, electron-deficient phenols can also be used as the acid component in this reaction. In addition, the synthetic utility of the present methodology was examined by the one-pot synthesis of oxindoles with a free -OH group at the benzylic position.