144128-45-0

Basic information

• Product Name: 9(2H)-Acridinone, 7-chloro-3-(3,4-dichlorophenyl)-1-[[3-[(diethylamino)methyl]phenyl]imino ]-1,3,4,10-tetrahydro-10-hydroxy-
• CAS NO: 144128-45-0
• Molecular Formula: C30H28Cl3N3O2
• Molecular Weight: 568.93
• Mol File: 144128-45-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9(2H)-Acridinone, 7-chloro-3-(3,4-dichlorophenyl)-1-[[3-[(diethylamino)methyl]phenyl]imino ]-1,3,4,10-tetrahydro-10-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 9(2H)-Acridinone, 7-chloro-3-(3,4-dichlorophenyl)-1-[[3-[(diethylamino)methyl]phenyl]imino ]-1,3,4,10-tetrahydro-10-hydroxy-(144128-45-0)
• EPA Substance Registry System: 9(2H)-Acridinone, 7-chloro-3-(3,4-dichlorophenyl)-1-[[3-[(diethylamino)methyl]phenyl]imino ]-1,3,4,10-tetrahydro-10-hydroxy-(144128-45-0)

Safety Data

• Hazardous Substances Data: 144128-45-0(Hazardous Substances Data)

Upstream product

• 75618-33-6 7-chloro-3-(3,4-dichlorophenyl)-3,4-dihydro-10-hydroxy-1,9(2H,10H)-acridinedione 
• 27958-97-0 3-(N,N-diethylamino-methyl)-aniline 

Relevant articles and documents

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.