1441307-06-7Relevant academic research and scientific papers
Palladium-catalyzed arylic/allylic aminations: Permutable domino sequences for the synthesis of dihydroquinolines from morita-baylis-hillman adducts
Lorion, Melanie M.,Gasperini, Danila,Oble, Julie,Poli, Giovanni
supporting information, p. 3050 - 3053 (2013/07/26)
An efficient palladium-catalyzed synthesis of 1,2-dihydroquinolines has been developed via the reaction between anilines and Morita-Baylis-Hillman adducts derived from o-bromobenzaldehyde. This new Pd(0)-catalyzed pseudo-domino type I sequence involves a Buchwald-Hartwig arylic amination and an allylic amination. When starting from an o-bromo allylic alcohol, the chronology is arylic amination/allylic arylation. However, the sequence reverses when the reaction is performed on the corresponding o-bromo allylic acetate.
