144202-85-7Relevant academic research and scientific papers
Synthesis of bicyclic N-methylpyrazoline and pyrazole derivatives from α,β-unsaturated ketones and N,N-dimethylhydrazine: An illustration of reductive cyclization
Panda,Das,Quail,Dimmock
, p. 219 - 223 (2014/02/14)
The reaction of N,N-dimethylhydrazine with α,β-unsaturated keto precursors such as 2-benzylidenecyclohexanone, 2,6-bis(benzylidene) cyclohexanone, and 3,5-bis(benzylidene)-1-methyl-4-piperidone hydrochloride provided bicyclic N-methylpyrazoles instead of hydrazones or any Michael addition products. The crystal structure of a representative pyrazole is reported. The proposed mechanism for the formation of the bicyclic N-methylpyrazole 1 is outlined.
Synthesis of hydrogenated indazole derivatives starting with α,β-unsaturated ketones and hydrazine derivatives
Nakhai, Azadeh,Bergman, Jan
experimental part, p. 2298 - 2306 (2009/07/11)
The reaction of hydrazine derivatives with α,β-unsaturated ketones, such as cyclohexenyl(phenyl)methanone and (E)-2-benzylidenecyclohexanone, were investigated. The reaction between methylhydrazine and e.g., cyclohexenyl(phenyl)methanone was particularly interesting as 3a,4,5,6,7,7a-hexahydro-1-methyl-3-phenyl-1H-indazole was obtained as the major product together with 4,5,6,7-tetrahydro-2-methyl-3-phenyl-2H-indazole as a minor product.
