144222-54-8

Basic information

• Product Name: dichloroacetic acid 1-phenyl-pent-4-enyl ester
• Synonyms: dichloroacetic acid 1-phenyl-pent-4-enyl ester
• CAS NO: 144222-54-8
• Molecular Weight: 273.159
• Mol File: 144222-54-8.mol

Chemical Properties

• CAS DataBase Reference: dichloroacetic acid 1-phenyl-pent-4-enyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: dichloroacetic acid 1-phenyl-pent-4-enyl ester(144222-54-8)
• EPA Substance Registry System: dichloroacetic acid 1-phenyl-pent-4-enyl ester(144222-54-8)

Safety Data

• Hazardous Substances Data: 144222-54-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 79-36-7 dichloroacethyl chloride 
• 102632-99-5 1-phenyl-4-penten-1-ol 

Downstream Products

• 144222-55-9 3,5-Dichloro-8-phenyl-oxocan-2-one 

Relevant articles and documents

Synthesis of medium-sized lactones by the copper(I)chloride/2,2′-bipyridine-catalyzed cyclization of di- and trichloroacetates

Medium-sized lactones (eight- to eleven-membered rings) are efficiently formed by Cu(bpy)Cl catalyzed cyclization of various alkenyl di- and trichloroacetates at temperatures between 80 and 190°C in 1,2-dichloroethane or benzene as solvents. The mechanism of the alkene addition reaction is best understood as a chlorine atom transfer process through radical type intermediates. Exclusive endo-cyclization is observed in all cases. Ten and eleven-membered lactones are only accessible by the 'rigid chain' approach, in which an alkyne or alkene function is incorporated in the chain connecting the reaction centres, thus reducing the flexibility of the molecule.