1442636-40-9

Basic information

• Product Name: C₇H₆N₂O₂S₂*C₆H₁₂N₂
• Synonyms: C₇H₆N₂O₂S₂*C₆H₁₂N₂
• CAS NO: 1442636-40-9
• Molecular Weight: 326.444
• Mol File: 1442636-40-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₇H₆N₂O₂S₂*C₆H₁₂N₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₇H₆N₂O₂S₂*C₆H₁₂N₂(1442636-40-9)
• EPA Substance Registry System: C₇H₆N₂O₂S₂*C₆H₁₂N₂(1442636-40-9)

Safety Data

• Hazardous Substances Data: 1442636-40-9(Hazardous Substances Data)

Upstream product

• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 75-15-0 carbon disulfide 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 2131-61-5 p-nitrophenyl isothiocyanate 

Relevant articles and documents

Facile and versatile synthesis of alkyl and aryl isothiocyanates by using triphosgene and cosolvent

A mild and efficient method for the conversion of alkyl and aryl amines to isothiocyanates via dithiocarbamates has been developed using (CH 3)2CO-CS2 as co-solvent and triphosgene as dehydrosulfurization reagent. High yields, mild reaction conditions and excellent functional group compatibility make it become a versatile synthetic method for the preparation of isothiocyanates compared with reported methods. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Synthesis, structure-activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase

A series of 4-thiazolidinone derivatives were synthesized and evaluated as novel human dihydroorotate dehydrogenase (hDHODH) inhibitors. Compounds 26 and 31 displayed IC50 values of 1.75 and 1.12 μM, respectively. The structure-activity relationship was summarized. Further binding mode analysis revealed that compound 31 could form a hydrogen bond with Tyr38 and a water-mediated hydrogen bond with Ala55, which may be necessary for maintaining the bioactivities of the compounds in this series. Further structural optimization of the para- or meta-position of the phenyl group at R will lead to the identification of more potent hDHODH inhibitors.