1442660-13-0

Basic information

• Product Name: (3,4-dimethoxyphenyl)(quinoxalin-5-yl)methanone
• Synonyms: (3,4-dimethoxyphenyl)(quinoxalin-5-yl)methanone
• CAS NO: 1442660-13-0
• Molecular Weight: 294.31
• Mol File: 1442660-13-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3,4-dimethoxyphenyl)(quinoxalin-5-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-dimethoxyphenyl)(quinoxalin-5-yl)methanone(1442660-13-0)
• EPA Substance Registry System: (3,4-dimethoxyphenyl)(quinoxalin-5-yl)methanone(1442660-13-0)

Safety Data

• Hazardous Substances Data: 1442660-13-0(Hazardous Substances Data)

Upstream product

• 6924-71-6 methyl quinoxaline-5-carboxylate 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 107582-20-7 2,3-diaminobenzoic acid methyl ester 
• 57113-91-4 methyl 3-nitroanthranilate 
• 606-18-8 3-nitroanthranilic acid 
• 112656-95-8 7-nitroindoline-2,3-dione 
• 88-74-4 2-nitro-aniline 
• 17122-60-0 2-(N-hydroxyimino)-N-(2-nitrophenyl)acetamide 

Relevant articles and documents

Catalytic formation of ketones from unactivated esters through rhodium chelation-assisted C-O bond activation

A new method for building aryl aryl ketones containing heterocyclic rings through chelation-assisted C-O bond activation catalyzed by a rhodium complex has been developed. In this reaction, methyl quinoline-8-carboxylate, methyl quinoxaline-5-carboxylate, and their derivatives were reacted with an excess amount of a substituted phenyl boronic acid in the presence of a rhodium(I) complex to give substituted phenyl(quinolin-8-yl)methanone, phenylquinoxalin-5- ylmethanone, and their derivatives in medium to high yields. The current method offers a highly favorable synthetic pathway to efficiently build related drugs with an 8-benzoylquinoline core structure. This method may prove especially valuable for medicinal chemists for the late-stage introduction of versatile ketone moieties into complex scaffolds for diversity-oriented synthetic strategies.