57113-91-4

Basic information

• Product Name: Methyl 2-amino-3-nitrobenzoate
• Synonyms: 3-Nitro-anthranilic Acid Methyl Ester;2-(Methoxycarbonyl)-6-nitroaniline, 2-Amino-3-(methoxycarbonyl)nitrobenzene, Methyl 3-nitroanthranilate;2-AMINO-3-NITROBENZOIC ACID METHYL ESTER;METHYL 2-AMINO-3-NITROBENZOATE;RARECHEM AH CK 0023;Methyl 3-nitroanthranilate;Methyl 2-amino-3-nitrobenzoate 95%;Benzoic acid, 2-amino-3-nitro-, methyl ester
• CAS NO: 57113-91-4
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• EINECS: 1312995-182-4
• Product Categories: Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Drug Intermediates;Aromatics;Aromatic Esters;Benzoic acid
• Mol File: 57113-91-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 97-98°C
• Boiling Point: 340.1 °C at 760 mmHg
• Flash Point: 159.5 °C
• Appearance: /
• Density: 1.386 g/cm³
• Vapor Pressure: 8.82E-05mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO, Ethyl Acetate
• PKA: -2.80±0.25(Predicted)
• CAS DataBase Reference: Methyl 2-amino-3-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-amino-3-nitrobenzoate(57113-91-4)
• EPA Substance Registry System: Methyl 2-amino-3-nitrobenzoate(57113-91-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 57113-91-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

An intermediate in the preparation of Candesartan.

InChI:InChI=1/C8H8N2O4/c1-14-8(11)5-3-2-4-6(7(5)9)10(12)13/h2-4H,9H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 606-18-8 3-nitroanthranilic acid 
• 136918-14-4 phthalimide 
• 96385-50-1 3-nitrophthalamide 
• 73833-13-3 acid chloride of 1-methylhydrogen-3-nitrophthalate 
• 21606-04-2 methyl 2-carboxy-3-nitrobenzoate 
• 603-11-2 3-nitrophthalic acid 
• 13365-26-9 dimethyl 3-nitrophthalate 
• 134-20-3 2-carbomethoxyaniline 
• 112656-95-8 7-nitroindoline-2,3-dione 
• 88-74-4 2-nitro-aniline 
• 17122-60-0 2-(N-hydroxyimino)-N-(2-nitrophenyl)acetamide 
• 77-78-1 dimethyl sulfate 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 181135-46-6 methyl 2-[4-(methyloxy)phenyl]-1H-benzimidazole-4-carboxylate 
• 181135-48-8 NU₁₀₇₆ 
• 181135-44-4 methyl 2-amino-3-N-(4'-methoxybenzoyl)aminobenzoate 
• 313278-92-1 methyl 2-trifluoromethyl-1H-benzimidazole-4-carboxylate 
• 188107-02-0 2-(4-nitro-phenyl)-1H-benzoimidazole-4-carboxylic acid methyl ester 
• 188106-90-3 NU₁₁₀₃ 
• 188107-00-8 2-(4-cyano-phenyl)-1H-benzoimidazole-4-carboxylic acid methyl ester 
• 188106-86-7 NU₁₀₉₂ 
• 188107-10-0 Methyl-2-amino-3-N-(4'-aminobenzoyl)aminobenzoate 
• 188107-06-4 methyl 2-amino-3-N-(3'-methoxybenzoyl)aminobenzoate 
• 188107-01-9 methyl 2-amino-3-N-(4'-nitrobenzoyl)aminobenzoate 
• 188106-99-2 Methyl 2-amino-3-N-(4'cyanobenzoyl)aminobenzoate 
• 188106-96-9 Methyl 2-amino-3-N-(4'-trifluoromethylbenzoyl)aminobenzoate 
• 188107-03-1 methyl 2-amino-3-N-(3'-trifluoromethylbenzoyl)aminobenzoate 

Relevant articles and documents

Method for preparing 2-amino-3-methyl nitrobenzoate

The invention discloses a method for preparing methyl 2-amino-3-nitrobenzoate, which comprises the following steps: pumping a phthalimide solution and a sodium hypochlorite solution into a micro-reaction mixer, reacting, reacting with water in a tubular reactor to obtain methyl anthranilate, and continuously separating to obtain a crude product; pumping the methyl anthranilate crude product, an acetic anhydride solution and fuming nitric acid into a micro-channel reactor, mixing, reacting to obtain N-methyl nitrobenzoate, and continuously separating to obtain a crude product; pumping an N-methyl nitrobenzoate solution, concentrated sulfuric acid and water into a micro-channel reactor, mixing, and reacting to obtain a 2-amino-3-methyl nitrobenzoate crude product; recrystallizing the crude product in methanol to obtain a product, namely methyl 2-amino-3-nitrobenzoate; and the method is high in yield, good in safety and suitable for industrial production.

A 2 - ethoxy benzimidazole - 7 - carboxylic acid methyl ester

The invention discloses a synthesis method of 2-ethoxy benzimidazole-7-carboxylic acid methyl ester. The problem that an existing process is not high in content and is very low in yield is solved. According to the synthesis method, 3-nitryl phthalic acid is used as a raw material, rearrangement is performed in a water solution after methyl esterification, acylation and re-nitridation, then tin powder is adopted to perform reduction and loop closing so as to obtain the 2-ethoxy benzimidazole-7-carboxylic acid methyl ester. By the adoption of the synthesis method, produced impurities are very little, the content is high, and the yield is also high.

ANTI-MALIGNANT TUMOR AGENT COMPOSITION

To provide a satisfactory anticancer agent composition suppressing the growth of cancer (malignant tumor) reliably and hardly causing side effects, the present invention is directed to an anticancer agent composition including the following agents as active ingredient; a LAT1 inhibitor, and one or more agents selected from the group consisting of an alkylating agent, a platinum-based antineoplastic agent, an anti-metabolite, a topoisomerase inhibitor, an anti-microtubule polymerizing agent, a hormonal agent, an anti-microtubule depolymerizing agent, an anticancer antibiotic, and a molecular targeted agent.