14428-41-2Relevant academic research and scientific papers
Benign and highly efficient synthesis of quinolines from 2-aminoarylketone or 2-aminoarylaldehyde and carbonyl compounds mediated by hydrochloric acid in water
Wang, Guan-Wu,Jia, Cheng-Sheng,Dong, Ya-Wei
, p. 1059 - 1063 (2006)
An environmentally friendly and highly efficient procedure for the preparation of substituted quinoline derivatives was developed by a simple Friedl?nder reaction of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of hydro
Efficient ultrasound-assisted synthesis, spectroscopic, crystallographic and biological investigations of pyrazole-appended quinolinyl chalcones
Prasath,Bhavana,Sarveswari,Ng, Seik Weng,Tiekink, Edward R.T.
, p. 201 - 210 (2015)
Two series of new quinolinyl chalcones containing a pyrazole group, 3a-f and 4a-r, have been synthesized by Claisen-Schmidt condensation of the derivatives of 2-methyl-3-acetylquinoline with either substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehyde or 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde in 76-93% yield under ultrasonic method. The compounds were characterized using IR, 1H NMR and ESI-MS spectroscopic methods and, for representative compounds, by X-ray crystallography. An E-configuration about the CC ethylene bond has been established via 1H NMR spectroscopy and X-ray crystallography. These compounds show promising anti-microbial properties, with 4a and 3e being the most potent against bacterial and fungal strains, respectively and the methoxy substituted compounds showed moderate anti-oxidant activity.
Magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid as a highly efficient and green heterogeneous catalyst for the synthesis of substituted quinolines and 1-amidoalkyl-2-naphthol derivatives
Katheriya, Deepak,Patel, Nipun,Dadhania, Harsh,Dadhania, Abhishek
, p. 805 - 816 (2020/10/02)
Abstract: Magnetically retrievable, magnetite (Fe3O4) nanoparticles-supported dodecylbenzenesulfonic acid (DDBSA@MNP) was synthesized and characterized through different analytical techniques such as TEM, XRD, FTIR, TGA, SEM, EDX and
An efficient and green microwave-assisted synthesis of quinoline derivatives via knoevengal condensation
Tasqeeruddin, Syed,Asiri, Yahya,Alsherhri, Jaber Abdullah
supporting information, p. 157 - 163 (2020/02/04)
We have developed an efficient and green synthesis of quinoline derivatives using L-proline under Knoevenagel condensation. L-proline was found to be an efficient catalyst for the Knoevenagel condensation of substituted 2-aminoaryl ketones 1 with the acti
A hydrazine functionalized UiO-66(Hf) metal-organic framework for the synthesis of quinolines via Friedl?nder condensation
Das, Aniruddha,Anbu, Nagaraj,Varalakshmi, Perumal,Dhakshinamoorthy, Amarajothi,Biswas, Shyam
, p. 10982 - 10988 (2020/08/21)
A hydrazine functionalized Hf-UiO-66 metal-organic framework (MOF) (called 1) was prepared using the traditional solvothermal method and it was characterized completely. The material showed high chemical stability in various solvent systems. The activated material (called 1′) was successfully used as a solid heterogeneous catalyst for the synthesis of quinolone scaffolds in a modified Friedl?nder synthesis. The catalyst was able to produce 95% yield of the product 3-acetyl-2,4-dimethylquinoline via Friedl?nder condensation of 2-aminoacetophenone and acetylacetone as starting materials at 100 °C. It also exhibited a broad substrate scope in this catalytic reaction. Various control experiments were carried out with respect to the activity of the presented catalyst which clearly indicated its active role. The stability and recyclability of the catalyst were also examined. A series of control experiments for this catalysis have shown that the Lewis acidic metal nodes and Br?nsted acidic -NHNH2 functional groups of linker play active roles in the catalysis.
Environmentally Friendly Nafion-Mediated Friedl?nder Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones
Chan, Chieh-Kai,Lai, Chien-Yu,Wang, Cheng-Chung
, p. 1779 - 1794 (2020/06/08)
An efficient and eco-friendly synthetic route for Friedl?nder quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.
An environmentally benign, green, and efficient ionic liquid catalyzed synthesis of Quinoline derivatives via Knoevenagel condensation
Tasqeeruddin, Syed,Asiri, Yahya I.
, p. 132 - 139 (2019/12/12)
The present investigation is in the interest of one-pot, environmentally friendly and efficient protocol for the synthesis of quinoline derivatives from 2-aminoarylketones and active methylene compounds in the presence of L-proline and ionic liquid 1,3-di
A mild and efficient Ga(OTF)3-catalysed Friedl?nder reaction for the synthesis of quinolines
Hassan, Hani Mutlak A.,Denetiu, Iuliana
, p. 838 - 844 (2019/08/01)
– The application of gallium triflate [Ga(OTf)3] for the synthesis of quinolines via the Friedl?nder reaction is described. This mild and straightforward method employed only 1 mol% of Ga(OTf)3 to deliver the quinoline products in excellent yields, demons
Highly efficient Br?nsted acid and Lewis acid catalysis systems for the Friedl?nder Quinoline synthesis
Zhou, Xiao-Yu,Chen, Xia,Wang, Liang-Guang
supporting information, p. 830 - 837 (2018/03/12)
The efficient and green Br?nsted acid or Lewis acid catalysis systems for the Friedl?nder synthesis of 2,3,4-trisubstituted quinolines from the condensation of 2-aminoarylketones and β-ketoesters/ketones had been developed. The results confirmed that 4-to
A Multifunctional Metal-Organic Framework for Oxidative C-O Coupling Involving Direct C-H Activation and Synthesis of Quinolines
Sharma, Vivekanand,De, Dinesh,Bharadwaj, Parimal K.
, p. 8195 - 8199 (2018/07/25)
A robust paddle-wheel Cu(II)-based metal-organic framework (MOF) 1, having dual functionalities, namely, Lewis acid and basic sites, has been explored as a heterogeneous catalyst. This MOF, because of its large void volume (10298 ?3, 67.6%), la
