144294-95-1

Upstream product

• 16714-25-3 2-azidobenzaldehyde 
• 67-56-1 methanol 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 144294-84-8 1-Acetyl-2-bromo-2-[bromo-(4-bromo-phenyl)-methyl]-1,2-dihydro-indol-3-one 
• 144294-78-0 1-Acetyl-2-[(4-bromo-phenyl)-chloro-methyl]-2-chloro-1,2-dihydro-indol-3-one 
• 96682-70-1 1-acetyl-2-(4-bromobenzylidene)indolin-3-one 

Relevant academic research and scientific papers

Gold(iii)-catalyzed azide-yne cyclization/O-H insertion cascade reaction for the expeditious construction of 3-alkoxy-4-quinolinone frameworks

A gold-catalyzed 6-endo-digazide-yne cyclization/O-H insertion cascade reaction of azide-tethered alkynes with alcohols has been developed, and it provides an expeditious access to 3-alkoxy-4-quinoline derivatives in good to high yields under mild and neutral reaction conditions with broad substrate generality. The utility of this method is emphasized by a scalable experiment and concise total synthesis of a bioactive natural product Leiokinine A, and other bioactive quinoline analogs.