1443-54-5

Usage

Uses

Used in Pharmaceutical Industry:
N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride is used as an analgesic agent for its potent pain-relieving properties. It is particularly effective in managing severe pain, such as post-surgical pain or chronic pain conditions, due to its high efficacy compared to other opioids.
Used in Research and Forensic Applications:
In the fields of research and forensic science, N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride serves as a certified reference material. It is utilized for the development, validation, and standardization of analytical methods and procedures related to opioid detection and quantification. This is crucial for ensuring the accuracy and reliability of test results in both research and forensic settings.
Used in Drug Abuse Prevention and Treatment:
Due to its high potential for abuse and the risk of fatal overdoses, N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride plays a significant role in drug abuse prevention and treatment programs. It is used to study the mechanisms of addiction, develop new treatment strategies, and improve the understanding of the risks associated with opioid use.
Used in Regulatory Compliance:
As a Schedule II compound, N-(1-Phenethyl-4-piperidyl)propionanilide hydrochloride is subject to strict regulatory controls. It is used in the development and enforcement of regulations aimed at preventing the diversion of opioids for illicit purposes and ensuring that these medications are used safely and responsibly in medical settings.

InChI:InChI=1/C22H28N2O.ClH/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19;/h3-12,21H,2,13-18H2,1H3;1H

Upstream product

• 79-03-8 propionyl chloride 
• 21409-26-7 (1-Phenethyl-piperidin-4-yl)-phenyl-amine 
• 62-53-3 aniline 
• 437-38-7 N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide 
• 39742-60-4 1-(2-phenylethyl)-4-piperidinone 
• 103-63-9 1-phenyl-2-bromoethane 
• 41979-39-9 4-piperidone hydrochloride 

Relevant academic research and scientific papers

Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE)

Fentanyl, also known as ‘jackpot’, is a synthetic opiate that is 50–100 times more potent than morphine. Clandestine laboratories produce analogues of fentanyl, known as fentalogues to circumvent legislation regarding its production. Three pyridyl fentalogues were synthesized and then hyperpolarized by signal amplification by reversible exchange (SABRE) to appraise the forensic potential of the technique. A maximum enhancement of -168-fold at 1.4 T was recorded for the ortho pyridyl 1H nuclei. Studies of the activation parameters for the three fentalogues revealed that the ratio of ligand loss trans to hydride and hydride loss in the complex [Ir(IMes)(L)3(H)2]+ (IMes=1,3-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene) ranged from 0.52 to 1.83. The fentalogue possessing the ratio closest to unity produced the largest enhancement subsequent to performing SABRE at earth's magnetic field. It was possible to hyperpolarize a pyridyl fentalogue selectively from a matrix that consisted largely of heroin (97 : 3 heroin:fentalogue) to validate the use of SABRE as a forensic tool.

An efficient, optimized synthesis of fentanyl and related analogs

The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy produced a panel of four fentanyls in excellent yields (73-78%) along with their more commonly encountered hydrochloride and citric acid salts. The following strategy offers the opportunity for the gram-scale, efficient production of this interesting class of opioid alkaloids.