1443124-84-2

Upstream product

• 2166-32-7 6-(4-methylphenyl)-3(2H)-pyridazinone 
• 922863-74-9 C₁₈H₁₅N₃O₃ 
• 1903-67-9 N,N-diethylpiperidine-4-carboxamide 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 619-23-8 3-Nitrobenzyl chloride 

Relevant academic research and scientific papers

Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors

2,6-Disubstituted pyridazinone 4 was identified by HTS as a novel acetylcholinesterase (AChE) inhibitor. Under SAR development, compound 17e stood out as displaying high AChE inhibitory activity and AChE/butyrylcholinesterase (BuChE) selectivity in vitro. Docking studies revealed that 17e might interact with the catalytic active site (CAS) and the peripheral anionic site (PAS) simultaneously. Based on this novel binding information, 6-ortho-tolylamino and N-ethyl-N-isopropylacetamide substituted piperidine were disclosed as new PAS and CAS binders.